Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression

This research was supported by grants from the National Institutes of Health (D.S.B. and R.A.N.), the Christopher Reeves Paralysis Foundation (D.S.B.), the Human Frontier Research Program (D.S.B.), and the Bristol-Myers Squibb Company (R.A.N.). V.S. is supported by a grant from the Deutsche Forschungsgemeinschaft (Emmy Noether Programm). R.A.N. is a member of the Keck Center for Integrative Neuroscience and the Silvo Conte Center for Neuroscience Research. D.S.B. is an established investigator for the American Heart Association.
Correspondence should be addressed to Roger A. Nicoll, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143.
Copyright © 2003 Society for Neuroscience 0270-6474/03/235503-04$15.00/0

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	Abstract	Full	Pdf
Jul 2003	736	423	933
Aug 2003	36	113	91
Sep 2003	25	110	69
Oct 2003	16	108	101
Nov 2003	20	93	74
Dec 2003	33	73	56
Total 2003	866	920	1324
Jan 2004	27	74	43
Feb 2004	24	121	80
Mar 2004	19	94	74
Apr 2004	17	58	43
May 2004	23	69	45
Jun 2004	8	51	30
Jul 2004	12	35	23
Aug 2004	28	71	40
Sep 2004	20	53	29
Oct 2004	16	34	31
Nov 2004	10	46	31
Dec 2004	23	34	18
Total 2004	227	740	487
Jan 2005	9	80	35
Feb 2005	11	47	19
Mar 2005	21	62	38
Apr 2005	6	64	34
May 2005	12	36	37
Jun 2005	7	40	36
Jul 2005	9	29	24
Aug 2005	10	35	25
Sep 2005	3	23	13
Oct 2005	10	42	30
Nov 2005	19	30	21
Dec 2005	10	42	23
Total 2005	127	530	335
Jan 2006	6	45	35
Feb 2006	5	43	20
Mar 2006	5	40	16
Apr 2006	9	39	27
May 2006	11	43	22
Jun 2006	5	21	13
Jul 2006	4	41	18
Aug 2006	2	27	23
Sep 2006	3	31	15
Oct 2006	6	40	33
Nov 2006	10	23	13
Dec 2006	4	26	23
Total 2006	70	419	258
Jan 2007	9	38	28
Feb 2007	2	37	20
Mar 2007	17	32	28
Apr 2007	8	22	15
May 2007	13	28	20
Jun 2007	6	23	16
Jul 2007	12	21	12
Aug 2007	7	19	13
Sep 2007	3	34	24
Oct 2007	5	28	13
Nov 2007	11	30	19
Dec 2007	2	16	6
Total 2007	95	328	214
Jan 2008	2	24	8
Feb 2008	3	21	11
Mar 2008	9	26	19
Apr 2008	5	25	18
May 2008	10	18	15
Jun 2008	10	17	11
Jul 2008	11	22	17
Aug 2008	3	22	13
Sep 2008	17	21	8
Oct 2008	14	23	16
Nov 2008	10	17	13
Dec 2008	5	14	17
Total 2008	99	250	166
Jan 2009	8	20	20
Feb 2009	2	21	17
Mar 2009	12	19	25
Apr 2009	7	17	13
May 2009	7	11	12
Jun 2009	5	30	16
Jul 2009	9	21	13
Aug 2009	6	19	16
Sep 2009	3	16	14
Oct 2009	7	13	16
Nov 2009	9	24	23
Dec 2009	10	14	12
Total 2009	85	225	197
Jan 2010	9	19	29
Feb 2010	2	9	13
Mar 2010	11	20	20
Apr 2010	9	19	15
May 2010	8	17	12
Jun 2010	3	17	10
Jul 2010	6	11	7
Aug 2010	4	16	21
Sep 2010	13	14	24
Oct 2010	18	14	22
Nov 2010	9	18	16
Dec 2010	5	18	11
Total 2010	97	192	200
Jan 2011	10	19	27
Feb 2011	7	16	10
Mar 2011	16	22	16
Apr 2011	15	17	15
May 2011	18	20	24
Jun 2011	7	10	19
Jul 2011	7	13	20
Aug 2011	18	8	24
Sep 2011	22	10	17
Oct 2011	43	14	28
Nov 2011	18	17	23
Dec 2011	14	5	18
Total 2011	195	171	241
Jan 2012	27	12	15
Feb 2012	25	16	25
Mar 2012	25	14	32
Apr 2012	25	21	22
May 2012	15	9	13
Jun 2012	33	25	16
Jul 2012	12	7	20
Aug 2012	26	18	17
Sep 2012	20	15	22
Oct 2012	26	8	22
Nov 2012	29	11	13
Dec 2012	35	8	26
Total 2012	298	164	243
Jan 2013	17	10	11
Feb 2013	27	15	21
Mar 2013	33	11	20
Apr 2013	15	8	29
May 2013	23	16	16
Jun 2013	18	8	19
Jul 2013	29	10	21
Aug 2013	12	9	24
Sep 2013	20	18	23
Oct 2013	9	14	20
Nov 2013	16	7	19
Dec 2013	12	14	18
Total 2013	231	140	241
Jan 2014	26	8	17
Feb 2014	24	9	21
Mar 2014	31	15	28
Apr 2014	38	6	22
May 2014	16	19	12
Jun 2014	19	8	5
Jul 2014	17	4	7
Aug 2014	12	5	21
Sep 2014	19	11	8
Oct 2014	19	8	10
Nov 2014	14	17	8
Dec 2014	15	13	5
Total 2014	250	123	164
Jan 2015	17	18	10
Feb 2015	8	5	2
Mar 2015	13	19	11
Apr 2015	17	12	11
May 2015	14	18	7
Jun 2015	19	15	13
Jul 2015	20	13	6
Aug 2015	10	11	5
Sep 2015	24	19	10
Oct 2015	20	4	24
Nov 2015	17	6	5
Dec 2015	11	3	2
Total 2015	190	143	106
Jan 2016	14	7	6
Feb 2016	24	9	6
Mar 2016	19	12	25
Apr 2016	6	11	9
May 2016	35	9	15
Jun 2016	11	7	12
Jul 2016	7	10	11
Aug 2016	6	8	14
Sep 2016	16	5	10
Oct 2016	5	9	7
Nov 2016	3	28	4
Dec 2016	5	18	7
Total 2016	151	133	126
Jan 2017	2	23	5
Feb 2017	8	17	9
Mar 2017	3	36	14
Apr 2017	6	18	34
May 2017	14	96	25
Jun 2017	3	19	6
Jul 2017	6	27	5
Aug 2017	3	25	4
Sep 2017	8	72	8
Oct 2017	10	103	10
Nov 2017	4	21	10
Dec 2017	4	14	8
Total 2017	71	471	138
Jan 2018	6	20	5
Feb 2018	3	15	10
Mar 2018	6	18	6
Apr 2018	2	30	13
May 2018	4	29	14
Jun 2018	1	32	8
Jul 2018	4	23	7
Aug 2018	2	38	8
Sep 2018	2	31	13
Oct 2018	2	29	10
Nov 2018	3	27	5
Dec 2018	3	33	6
Total 2018	38	325	105
Jan 2019	3	24	7
Feb 2019	2	25	9
Mar 2019	7	27	14
Apr 2019	2	29	11
May 2019	3	43	16
Jun 2019	4	26	9
Jul 2019	4	17	15
Aug 2019	1	32	11
Sep 2019	3	43	11
Oct 2019	5	44	7
Nov 2019	4	16	11
Dec 2019	4	29	8
Total 2019	42	355	129
Jan 2020	3	27	9
Feb 2020	2	25	7
Mar 2020	3	19	11
Apr 2020	6	15	11
May 2020	8	12	9
Jun 2020	4	2	4
Jul 2020	1	12	3
Aug 2020	2	10	14
Sep 2020	4	35	14
Oct 2020	4	34	13
Total 2020	37	191	95
Total	3169	5820	4769