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Development/Plasticity/Repair

Alteration of Gene Expression by Chromosome Loss in the Postnatal Mouse Brain

Dhruv Kaushal, James J. A. Contos, Kai Treuner, Amy H. Yang, Marcy A. Kingsbury, Stevens K. Rehen, Michael J. McConnell, Masaru Okabe, Carrolee Barlow and Jerold Chun
Journal of Neuroscience 2 July 2003, 23 (13) 5599-5606; DOI: https://doi.org/10.1523/JNEUROSCI.23-13-05599.2003
Dhruv Kaushal
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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James J. A. Contos
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Kai Treuner
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Amy H. Yang
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Marcy A. Kingsbury
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Stevens K. Rehen
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Michael J. McConnell
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Masaru Okabe
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Carrolee Barlow
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Jerold Chun
1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-13-05599.2003
PubMed 
12843262
Published By 
Society for Neuroscience
History 
  • Received August 28, 2002
  • Revision received April 4, 2003
  • Accepted April 7, 2003
  • First published July 2, 2003.
  • Version of record published July 2, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/235599-08.00/0

Author Information

  1. Dhruv Kaushal1,3,
  2. James J. A. Contos3,
  3. Kai Treuner5,
  4. Amy H. Yang2,3,
  5. Marcy A. Kingsbury3,
  6. Stevens K. Rehen3,
  7. Michael J. McConnell2,3,5,
  8. Masaru Okabe4,
  9. Carrolee Barlow5, and
  10. Jerold Chun1,2,3
  1. 1Neuroscience and 2Biomedical Sciences Programs, and 3Department of Pharmacology, University of California, San Diego, San Diego, California 92093, 4Genome Information Research Center, Osaka University, Suita, Osaka, 565-0871 Japan, 5Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037
View Full Text

Author contributions

Disclosures

    • Received August 28, 2002.
    • Revision received April 4, 2003.
    • Accepted April 7, 2003.
  • This work was supported by an unrestricted gift from Merck (J.C.), predoctoral funding from the Pharmaceutical Research and Manufacturers Association foundation (D.K.) and National Institute of General Medical Sciences (M.J.M. and A.H.Y.), and postdoctoral funding from the Pew Foundation (S.K.R.) and National Institute of Mental Health (M.A.K.). We thank Dr. Fred Gage for critical reading of this manuscript and helpful discussions. We are grateful to Marisa Fontanoz, Grace Kennedy, and Carol Akita for technical assistance, and Dennis Young and the University of California, San Diego flow cytometry shared resource for flow sorting.

  • Correspondence should be addressed to Dr. Jerold Chun, Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND-118, La Jolla, CA 92037. E-mail: jchun{at}scripps.edu.

  • D. Kaushal's, A. Yang's, M. Kingsbury's, S. Rehen's, and M. McConnell's present address: Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037.

  • J. Contos' present address: Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

  • C. Barlow's present address: Merck Research Labs, San Diego, CA 92121.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/235599-08$15.00/0

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AbstractFullPdf
Jul 2003253176238
Aug 2003279972
Sep 2003157947
Oct 20032910045
Nov 2003208756
Dec 2003194426
Total 2003363585484
Jan 2004174024
Feb 2004124421
Mar 2004446228
Apr 2004253712
May 2004174220
Jun 2004214514
Jul 2004195321
Aug 2004295922
Sep 2004224230
Oct 2004184330
Nov 2004126023
Dec 2004284921
Total 2004264576266
Jan 2005184420
Feb 2005186126
Mar 2005294140
Apr 200556435
May 200583720
Jun 2005164326
Jul 200562732
Aug 200572210
Sep 200572221
Oct 2005112213
Nov 2005132918
Dec 20059179
Total 2005147429270
Jan 200664713
Feb 200661911
Mar 2006103619
Apr 20065238
May 2006122211
Jun 20066238
Jul 2006389
Aug 200673116
Sep 20064199
Oct 200673510
Nov 200682913
Dec 200622911
Total 200676321138
Jan 20078248
Feb 200731817
Mar 20076289
Apr 20078299
May 20072186
Jun 2007122112
Jul 200732417
Aug 20072129
Sep 20079156
Oct 200792415
Nov 2007132112
Dec 200771610
Total 200782250130
Jan 2008112614
Feb 200871012
Mar 2008151812
Apr 2008162014
May 2008121817
Jun 2008163210
Jul 2008111110
Aug 200815289
Sep 200818153
Oct 200811153
Nov 200813168
Dec 2008593
Total 2008150218115
Jan 20094119
Feb 20098184
Mar 2009172216
Apr 200951712
May 20096108
Jun 2009101412
Jul 200911176
Aug 20094135
Sep 2009585
Oct 200951013
Nov 2009593
Dec 20091035
Total 20099015298
Jan 20108135
Feb 201011125
Mar 201010215
Apr 2010964
May 201042011
Jun 20103137
Jul 2010897
Aug 2010795
Sep 20107159
Oct 201072212
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Dec 201072323
Total 201088180106
Jan 20118910
Feb 201171113
Mar 201110137
Apr 20113138
May 2011101824
Jun 201141225
Jul 20112223
Aug 2011101330
Sep 2011694
Oct 2011151013
Nov 201110715
Dec 20119811
Total 201194125183
Jan 20128912
Feb 201261027
Mar 2012302216
Apr 2012102010
May 201219713
Jun 20126614
Jul 201272115
Aug 2012231420
Sep 201212106
Oct 2012121513
Nov 2012311017
Dec 201229177
Total 2012193161170
Jan 201316813
Feb 2013241112
Mar 2013181613
Apr 201311109
May 2013201710
Jun 201381013
Jul 20131153
Aug 2013944
Sep 20132058
Oct 201311911
Nov 20136611
Dec 20131896
Total 2013172110113
Jan 201415917
Feb 2014131036
Mar 2014181322
Apr 2014151021
May 2014888
Jun 20148916
Jul 2014152029
Aug 201451017
Sep 201461816
Oct 20145217
Nov 20149209
Dec 201412288
Total 2014129176206
Jan 20157322
Feb 201519146
Mar 20158226
Apr 2015552
May 2015764
Jun 201510118
Jul 2015780
Aug 201538105
Sep 20151534
Oct 20151372
Nov 20151467
Dec 20151687
Total 201515913253
Jan 2016544
Feb 201617610
Mar 201661313
Apr 2016683
May 2016552
Jun 2016553
Jul 2016641
Aug 2016756
Sep 20163121
Oct 2016450
Nov 20165105
Dec 2016254
Total 2016718252
Jan 20173114
Feb 2017151
Mar 20171177
Apr 20170913
May 20173307
Jun 2017081
Jul 20171146
Aug 2017084
Sep 20171101
Oct 2017141
Nov 20171151
Dec 2017251
Total 20171413647
Jan 2018081
Feb 20184176
Mar 20181101
Apr 20180101
May 20180160
Jun 20181248
Jul 20183143
Aug 20181123
Sep 20180141
Oct 20183131
Nov 20181123
Dec 20183140
Total 20181716428
Jan 20192186
Feb 20190211
Mar 20191134
Apr 20190253
May 20193274
Jun 20190226
Jul 201941410
Aug 201933711
Sep 201912011
Oct 20192165
Nov 20191166
Dec 20191153
Total 20191824470
Jan 2020490
Feb 20204176
Mar 20201122
Apr 20200142
May 2020185
Jun 2020123
Jul 2020183
Aug 20200121
Sep 20205145
Oct 20202168
Nov 20202258
Dec 202051615
Total 20202615358
Jan 202122013
Feb 202121310
Total 202143323
Total215742272610
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The Journal of Neuroscience: 23 (13)
Journal of Neuroscience
Vol. 23, Issue 13
2 Jul 2003
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Alteration of Gene Expression by Chromosome Loss in the Postnatal Mouse Brain
Dhruv Kaushal, James J. A. Contos, Kai Treuner, Amy H. Yang, Marcy A. Kingsbury, Stevens K. Rehen, Michael J. McConnell, Masaru Okabe, Carrolee Barlow, Jerold Chun
Journal of Neuroscience 2 July 2003, 23 (13) 5599-5606; DOI: 10.1523/JNEUROSCI.23-13-05599.2003

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Alteration of Gene Expression by Chromosome Loss in the Postnatal Mouse Brain
Dhruv Kaushal, James J. A. Contos, Kai Treuner, Amy H. Yang, Marcy A. Kingsbury, Stevens K. Rehen, Michael J. McConnell, Masaru Okabe, Carrolee Barlow, Jerold Chun
Journal of Neuroscience 2 July 2003, 23 (13) 5599-5606; DOI: 10.1523/JNEUROSCI.23-13-05599.2003
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Keywords

  • stem cells
  • aneuploidy
  • loss of heterozygosity
  • mosaicism
  • olfactory bulb
  • gene expression profiling

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