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Behavioral/Systems/Cognitive

Cyclic Estrogen Replacement Improves Cognitive Function in Aged Ovariectomized Rhesus Monkeys

Peter R. Rapp, John H. Morrison and Jeffrey A. Roberts
Journal of Neuroscience 2 July 2003, 23 (13) 5708-5714; https://doi.org/10.1523/JNEUROSCI.23-13-05708.2003
Peter R. Rapp
1Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029-6574, and 2California National Primate Research Center, University of California, Davis, Davis, California 95616-8615
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John H. Morrison
1Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029-6574, and 2California National Primate Research Center, University of California, Davis, Davis, California 95616-8615
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Jeffrey A. Roberts
1Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029-6574, and 2California National Primate Research Center, University of California, Davis, Davis, California 95616-8615
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    Figure 1.

    Schematic representation of the neuropsychological test battery. Left, DR; red dot signifies food reward; middle, DNMS; and right, two-choice OD. +, Baited; –, unbaited.

  • Figure 2.
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    Figure 2.

    Mean serum estradiol (E2) levels in aged OVX monkeys 1 d before, and 9 hr, 2 d, and 3 d after vehicle or hormone injection. The results include data from every monkey, but not all time points were evaluated in each subject.

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    Figure 3.

    Neuropsychological performance in aged OVX-veh and OVX-E monkeys. Top, Mean number of trials required to reach the acquisition criterion on the DR task at 0 and 1 sec delays (left), and mean percent correct across delays of 5–60 sec (right). Middle, Mean trials required to learn the DNMS procedure with a 10 sec delay (left), and mean percent correct across retention intervals of 15–600 sec (right). Bottom, Mean percent correct across 10-trial blocks of object discrimination learning (days 1 and 2), and retention after 48 hr (day 3). With the exception of one case in which an OVX-E animal completed only three problems, scores for individual animals were averaged across four discriminations. Error bars indicate SEM.

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    Figure 4.

    Neuropsychological performance in aged OVX-veh and OVX-E monkeys relative to young intact subjects. Top, Delay component of DR; middle, DNMS; bottom, OD, organized as in Figure 3. Error bars indicate SEM.

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The Journal of Neuroscience: 23 (13)
Journal of Neuroscience
Vol. 23, Issue 13
2 Jul 2003
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Cyclic Estrogen Replacement Improves Cognitive Function in Aged Ovariectomized Rhesus Monkeys
Peter R. Rapp, John H. Morrison, Jeffrey A. Roberts
Journal of Neuroscience 2 July 2003, 23 (13) 5708-5714; DOI: 10.1523/JNEUROSCI.23-13-05708.2003

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Cyclic Estrogen Replacement Improves Cognitive Function in Aged Ovariectomized Rhesus Monkeys
Peter R. Rapp, John H. Morrison, Jeffrey A. Roberts
Journal of Neuroscience 2 July 2003, 23 (13) 5708-5714; DOI: 10.1523/JNEUROSCI.23-13-05708.2003
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Keywords

  • menopause
  • hormone replacement
  • cognitive aging
  • monkey
  • hippocampus
  • prefrontal cortex

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