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Behavioral/Systems/Cognitive

Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, Manigé Fartasch, Gisela Heyer, Per S. Skov, Thomas A. Luger and Martin Schmelz
Journal of Neuroscience 16 July 2003, 23 (15) 6176-6180; https://doi.org/10.1523/JNEUROSCI.23-15-06176.2003
Martin Steinhoff
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Ulrich Neisius
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Akihiko Ikoma
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Manigé Fartasch
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Gisela Heyer
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Per S. Skov
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Thomas A. Luger
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Martin Schmelz
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-15-06176.2003
PubMed 
12867500
Published By 
Society for Neuroscience
History 
  • Received November 13, 2002
  • Revision received April 18, 2003
  • Accepted May 2, 2003
  • First published July 16, 2003.
  • Version of record published July 16, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/236176-05.00/0

Author Information

  1. Martin Steinhoff4,*,
  2. Ulrich Neisius1,2,*,
  3. Akihiko Ikoma1,
  4. Manigé Fartasch2,
  5. Gisela Heyer2,
  6. Per S. Skov3,
  7. Thomas A. Luger4, and
  8. Martin Schmelz1,5
  1. Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Author contributions

Disclosures

    • Received November 13, 2002.
    • Revision received April 18, 2003.
    • Accepted May 2, 2003.
  • This work was supported by the Deutsche Forschungsgemeinschaft[Sonderforschungsbereich (SFB) 293 and SFB 353]. We thank the referees for their most valuable comments.

  • Correspondence should be addressed to Dr. Martin Schmelz, Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68135 Mannheim, Germany. E-mail: martin.schmelz{at}anaes.ma.uni-heidelberg.de.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/236176-05$15.00/0

  • ↵* M.S. and U.N. contributed equally to this work.

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The Journal of Neuroscience: 23 (15)
Journal of Neuroscience
Vol. 23, Issue 15
16 Jul 2003
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Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, Manigé Fartasch, Gisela Heyer, Per S. Skov, Thomas A. Luger, Martin Schmelz
Journal of Neuroscience 16 July 2003, 23 (15) 6176-6180; DOI: 10.1523/JNEUROSCI.23-15-06176.2003

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Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, Manigé Fartasch, Gisela Heyer, Per S. Skov, Thomas A. Luger, Martin Schmelz
Journal of Neuroscience 16 July 2003, 23 (15) 6176-6180; DOI: 10.1523/JNEUROSCI.23-15-06176.2003
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Keywords

  • protease-activated receptors
  • neuroimmunology
  • neurophysiology
  • sensory nerve
  • atopy
  • tryptase

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