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Behavioral/Systems/Cognitive

Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, Manigé Fartasch, Gisela Heyer, Per S. Skov, Thomas A. Luger and Martin Schmelz
Journal of Neuroscience 16 July 2003, 23 (15) 6176-6180; https://doi.org/10.1523/JNEUROSCI.23-15-06176.2003
Martin Steinhoff
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Ulrich Neisius
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Akihiko Ikoma
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Manigé Fartasch
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Gisela Heyer
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Per S. Skov
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Thomas A. Luger
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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Martin Schmelz
Departments of 1Physiology and Experimental Pathophysiology, and 2Dermatology, University of Erlangen, 91054 Erlangen, Germany, 3The Reference Laboratory, University of Copenhagen, 2100 Copenhagen, Denmark, 4Department of Dermatology, University of Münster, 48149 Münster, Germany, and 5Department of Anesthesiology and Intensive Care Medicine, University of Heidelberg, 68135 Mannheim, Germany
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The Journal of Neuroscience: 23 (15)
Journal of Neuroscience
Vol. 23, Issue 15
16 Jul 2003
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Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, Manigé Fartasch, Gisela Heyer, Per S. Skov, Thomas A. Luger, Martin Schmelz
Journal of Neuroscience 16 July 2003, 23 (15) 6176-6180; DOI: 10.1523/JNEUROSCI.23-15-06176.2003

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Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, Manigé Fartasch, Gisela Heyer, Per S. Skov, Thomas A. Luger, Martin Schmelz
Journal of Neuroscience 16 July 2003, 23 (15) 6176-6180; DOI: 10.1523/JNEUROSCI.23-15-06176.2003
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Keywords

  • protease-activated receptors
  • neuroimmunology
  • neurophysiology
  • sensory nerve
  • atopy
  • tryptase

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