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Behavioral/Systems/Cognitive

Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry

Simon J. G. Lewis, Anja Dove, Trevor W. Robbins, Roger A. Barker and Adrian M. Owen
Journal of Neuroscience 16 July 2003, 23 (15) 6351-6356; https://doi.org/10.1523/JNEUROSCI.23-15-06351.2003
Simon J. G. Lewis
1Cambridge Centre for Brain Repair and Departments of 2Neurology and 3Experimental Psychology, University of Cambridge, and 4Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom CB2 2EF
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Anja Dove
1Cambridge Centre for Brain Repair and Departments of 2Neurology and 3Experimental Psychology, University of Cambridge, and 4Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom CB2 2EF
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Trevor W. Robbins
1Cambridge Centre for Brain Repair and Departments of 2Neurology and 3Experimental Psychology, University of Cambridge, and 4Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom CB2 2EF
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Roger A. Barker
1Cambridge Centre for Brain Repair and Departments of 2Neurology and 3Experimental Psychology, University of Cambridge, and 4Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom CB2 2EF
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Adrian M. Owen
1Cambridge Centre for Brain Repair and Departments of 2Neurology and 3Experimental Psychology, University of Cambridge, and 4Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom CB2 2EF
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-15-06351.2003
PubMed 
12867520
Published By 
Society for Neuroscience
History 
  • Received January 21, 2003
  • Revision received April 29, 2003
  • Accepted May 16, 2003
  • First published July 16, 2003.
  • Version of record published July 16, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/236351-06.00/0

Author Information

  1. Simon J. G. Lewis1,2,
  2. Anja Dove4,
  3. Trevor W. Robbins3,
  4. Roger A. Barker1,2,*, and
  5. Adrian M. Owen4,*
  1. 1Cambridge Centre for Brain Repair and Departments of 2Neurology and 3Experimental Psychology, University of Cambridge, and 4Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom CB2 2EF
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Author contributions

Disclosures

    • Received January 21, 2003.
    • Revision received April 29, 2003.
    • Accepted May 16, 2003.
  • This study was conducted as part of a Medical Research Council cooperative group grant, The Origins of Parkinson's Disease and Its Heterogeneity (G0001067), and in collaboration with the Medical Research Council Behavioural and Clinical Neuroscience Centre. This work was assisted by a Parkinson's Disease Society project grant and the British Medical Association's Vera Down Award. We thank the efforts of Drs. Matthew Brett and Rhodri Cusack of the Medical Research Council Cognition and Brain Sciences Unit along with Dr. Adrian Carpenter and his dedicated staff at the Wolfson Brain Imaging Centre (Cambridge, UK).

  • Correspondence should be addressed to Dr. Simon J. G. Lewis, Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke's Hospital, Cambridge, CB2 2PY, UK. E-mail: sjgl2{at}wbic.cam.ac.uk.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/236351-06$15.00/0

  • ↵* R.A.B. and A.M.O. are joint senior authors.

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The Journal of Neuroscience: 23 (15)
Journal of Neuroscience
Vol. 23, Issue 15
16 Jul 2003
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Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry
Simon J. G. Lewis, Anja Dove, Trevor W. Robbins, Roger A. Barker, Adrian M. Owen
Journal of Neuroscience 16 July 2003, 23 (15) 6351-6356; DOI: 10.1523/JNEUROSCI.23-15-06351.2003

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Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry
Simon J. G. Lewis, Anja Dove, Trevor W. Robbins, Roger A. Barker, Adrian M. Owen
Journal of Neuroscience 16 July 2003, 23 (15) 6351-6356; DOI: 10.1523/JNEUROSCI.23-15-06351.2003
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Keywords

  • Parkinson's disease
  • working memory
  • functional MRI
  • heterogeneity
  • frontal lobes
  • basal ganglia

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