Article Figures & Data
Figures
- Figure 1.
Statistical parametric maps showing significant engagement of the hippocampal formation (hippocampus and parahippocampal gyrus) during encoding and retrieval. BOLD fMRI responses in the posterior hippocampal formation are shown overlaid onto averaged structural MRIs in the axial, coronal, and sagittal plane. Blue cross-hairs are centered on the left hippocampal formation clusters during encoding and retrieval that contributed maximally to the observed variance in memory performance (see Regression analysis in Materials and Methods). a, Talairach coordinates and voxel-level statistics for the maximal voxel in the left and right hippocampal formation during encoding are x =-25 mm; y =-44 mm; z = -10 mm; cluster size = 42 voxels; voxel-level corrected p < 0.001; Z score = 5.59; and x = 22 mm; y = -48 mm; z = -10 mm; cluster size = 60 voxels; voxel-level corrected p < 0.001; Z score = 7.24, respectively. b, Talairach coordinates and voxel-level statistics for the maximal voxel in the left and right HF during retrieval are x = -25 mm; y = -44 mm; z = -10 mm; cluster size = 36 voxels; voxel-level corrected p < 0.001; Z score = 6.32; and x = 22 mm; y =-48 mm; z = -10 mm; cluster size = 64 voxels; voxel-level corrected p < 0.001; Z score = 7.08, respectively.
- Figure 2.
Genotype-based parametric comparisons showing significantly greater hippocampal activity in the Val group versus the Met group during both encoding and retrieval. BOLD fMRI responses in the posterior hippocampal formation are shown overlaid onto averaged structural MRIs in the coronal and sagittal plane. a, Talairach coordinates and voxel-level statistics for the maximal voxels in the right hippocampus and parahippocampal gyrus exhibiting Val greater than Met activity during encoding: x = 30 mm; y =-19 mm; z = -12 mm; cluster size = 5 voxels; voxel-level corrected p = 0.047; Z score = 1.91; and x = 22 mm; y = -44 mm; z = -6 mm; cluster size = 6 voxels; voxel-level corrected p = 0.043; Z score = 1.97, respectively. b, Talairach coordinates and voxel-level statistics for the maximal voxels in the left and right parahippocampal gyrus exhibiting Val greater than Met activity during retrieval: x = -30 mm; y = -44 mm; z = -2 mm; cluster size = 3 voxels; voxel-level corrected p = 0.046; Z score = 1.87; and x = 22 mm; y =-48 mm; z = -6 mm; cluster size = 7 voxels; voxel-level corrected p = 0.035; Z score = 2.45, respectively.
