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Cellular/Molecular

Prolonged Photoresponses and Defective Adaptation in Rods of Gβ5-/- Mice

Claudia M. Krispel, Ching-Kang Chen, Melvin I. Simon and Marie E. Burns
Journal of Neuroscience 6 August 2003, 23 (18) 6965-6971; https://doi.org/10.1523/JNEUROSCI.23-18-06965.2003
Claudia M. Krispel
1Center for Neuroscience and 2Department of Psychiatry, University of California, Davis, Davis, California 95616, 3Department of Ophthalmology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, and 4Division of Biology, California Institute of Technology, Pasadena, California 91125
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Ching-Kang Chen
1Center for Neuroscience and 2Department of Psychiatry, University of California, Davis, Davis, California 95616, 3Department of Ophthalmology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, and 4Division of Biology, California Institute of Technology, Pasadena, California 91125
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Melvin I. Simon
1Center for Neuroscience and 2Department of Psychiatry, University of California, Davis, Davis, California 95616, 3Department of Ophthalmology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, and 4Division of Biology, California Institute of Technology, Pasadena, California 91125
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Marie E. Burns
1Center for Neuroscience and 2Department of Psychiatry, University of California, Davis, Davis, California 95616, 3Department of Ophthalmology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, and 4Division of Biology, California Institute of Technology, Pasadena, California 91125
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-18-06965.2003
PubMed 
12904457
Published By 
Society for Neuroscience
History 
  • Received February 26, 2003
  • Revision received June 3, 2003
  • Accepted June 5, 2003
  • First published August 6, 2003.
  • Version of record published August 6, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/236965-07.00/0

Author Information

  1. Claudia M. Krispel1,2,
  2. Ching-Kang Chen3,
  3. Melvin I. Simon4, and
  4. Marie E. Burns1,2
  1. 1Center for Neuroscience and 2Department of Psychiatry, University of California, Davis, Davis, California 95616, 3Department of Ophthalmology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, and 4Division of Biology, California Institute of Technology, Pasadena, California 91125
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Author contributions

Disclosures

    • Received February 26, 2003.
    • Revision received June 3, 2003.
    • Accepted June 5, 2003.
  • This work was supported by the National Institutes of Health Vision Core Grant EY12576-01 to University of California, Davis; University of California, Davis, School of Medicine MD/PhD program (C.M.K.); and individual National Institutes of Health Grants EY14047-01 (M.E.B.) and AG12288 (M.I.S.). M.E.B. is an Alfred P. Sloan research fellow.

  • Correspondence should be addressed to Dr. Marie E. Burns, Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616. E-mail: meburns{at}ucdavis.edu.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/236965-07$15.00/0

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The Journal of Neuroscience: 23 (18)
Journal of Neuroscience
Vol. 23, Issue 18
6 Aug 2003
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Prolonged Photoresponses and Defective Adaptation in Rods of Gβ5-/- Mice
Claudia M. Krispel, Ching-Kang Chen, Melvin I. Simon, Marie E. Burns
Journal of Neuroscience 6 August 2003, 23 (18) 6965-6971; DOI: 10.1523/JNEUROSCI.23-18-06965.2003

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Prolonged Photoresponses and Defective Adaptation in Rods of Gβ5-/- Mice
Claudia M. Krispel, Ching-Kang Chen, Melvin I. Simon, Marie E. Burns
Journal of Neuroscience 6 August 2003, 23 (18) 6965-6971; DOI: 10.1523/JNEUROSCI.23-18-06965.2003
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Keywords

  • phototransduction
  • G-protein
  • transducin
  • adaptation
  • RGS
  • calcium
  • cGMP

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