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Cellular/Molecular

Characterization of a Neurotrophin Signaling Mechanism that Mediates Neuron Survival in a Temporally Specific Pattern

Aryaman Shalizi, Maria Lehtinen, Brice Gaudillière, Nicole Donovan, Jiahuai Han, Yoshiyuki Konishi and Azad Bonni
Journal of Neuroscience 13 August 2003, 23 (19) 7326-7336; https://doi.org/10.1523/JNEUROSCI.23-19-07326.2003
Aryaman Shalizi
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Maria Lehtinen
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Brice Gaudillière
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Nicole Donovan
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Jiahuai Han
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Yoshiyuki Konishi
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Azad Bonni
1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-19-07326.2003
PubMed 
12917366
Published By 
Society for Neuroscience
History 
  • Received March 4, 2003
  • Revision received May 5, 2003
  • Accepted May 13, 2003
  • First published August 13, 2003.
  • Version of record published August 13, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/237326-11.00/0

Author Information

  1. Aryaman Shalizi1,2,
  2. Maria Lehtinen1,3,
  3. Brice Gaudillière1,2,
  4. Nicole Donovan1,
  5. Jiahuai Han4,
  6. Yoshiyuki Konishi1, and
  7. Azad Bonni1,2,3
  1. 1Department of Pathology and Programs in 2Biological and Biomedical Sciences and 3Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
View Full Text

Author contributions

Disclosures

    • Received March 4, 2003.
    • Revision received May 5, 2003.
    • Accepted May 13, 2003.
  • This work was supported by a Burroughs Wellcome Career Development Award (A.B.), National Institutes of Health Grant R01-NS41021-01 (A.B.), an MPM scholar award (A.S.), an Albert J. Ryan Foundation award (A.S.), and a National Science Foundation graduate research fellowship (M.L.). A.B. is the recipient of a fellowship from the Alfred P. Sloan Foundation, a Robert H. Ebert Clinical Scholar Award from the Esther A. and Joseph Klingenstein Fund, an EJLB Foundation award, and a Sidney Kimmel Foundation Award. We thank S. Gutkind for providing the ERK5 and MEK5 plasmids, E. Olson for the MEF2 plasmids, A. Shintani for the NT-3 promoter plasmids, and S. Vasquez for technical assistance.

  • Correspondence should be addressed to Dr. Azad Bonni, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115. E-mail: azad_bonni{at}hms.harvard.edu.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/237326-11$15.00/0

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The Journal of Neuroscience: 23 (19)
Journal of Neuroscience
Vol. 23, Issue 19
13 Aug 2003
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Characterization of a Neurotrophin Signaling Mechanism that Mediates Neuron Survival in a Temporally Specific Pattern
Aryaman Shalizi, Maria Lehtinen, Brice Gaudillière, Nicole Donovan, Jiahuai Han, Yoshiyuki Konishi, Azad Bonni
Journal of Neuroscience 13 August 2003, 23 (19) 7326-7336; DOI: 10.1523/JNEUROSCI.23-19-07326.2003

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Characterization of a Neurotrophin Signaling Mechanism that Mediates Neuron Survival in a Temporally Specific Pattern
Aryaman Shalizi, Maria Lehtinen, Brice Gaudillière, Nicole Donovan, Jiahuai Han, Yoshiyuki Konishi, Azad Bonni
Journal of Neuroscience 13 August 2003, 23 (19) 7326-7336; DOI: 10.1523/JNEUROSCI.23-19-07326.2003
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Keywords

  • BDNF
  • ERK5
  • MEF2
  • CREB
  • NT-3
  • neuron
  • apoptosis
  • survival
  • transcription

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