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Molecular-Imaging Probe 2-(1-{6-[(2-Fluoroethyl)(Methyl) Amino]-2-Naphthyl}Ethylidene) Malononitrile Labels Prion Plaques In Vitro

Mara Bresjanac, Lojze M. Smid, Tomaz D. Vovko, Andrej Petrič, Jorge R. Barrio and Mara Popovic
Journal of Neuroscience 3 September 2003, 23 (22) 8029-8033; DOI: https://doi.org/10.1523/JNEUROSCI.23-22-08029.2003
Mara Bresjanac
1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Lojze M. Smid
1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Tomaz D. Vovko
1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Andrej Petrič
1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Jorge R. Barrio
1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Mara Popovic
1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-22-08029.2003
PubMed 
12954864
Published By 
Society for Neuroscience
History 
  • Received April 8, 2003
  • Revision received May 27, 2003
  • Accepted July 14, 2003
  • First published September 3, 2003.
  • Version of record published September 3, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/238029-05.00/0

Author Information

  1. Mara Bresjanac1,2,
  2. Lojze M. Smid1,2,
  3. Tomaz D. Vovko1,2,
  4. Andrej Petrič3,
  5. Jorge R. Barrio4, and
  6. Mara Popovic2
  1. 1Laboratory for Neuronal Plasticity and Regeneration, Institute of Pathophysiology, 2Prion Laboratory, Institute of Pathology, School of Medicine, and 3Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia, and 4Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095
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Author contributions

Disclosures

    • Received April 8, 2003.
    • Revision received May 27, 2003.
    • Accepted July 14, 2003.
  • This work was supported by the Republic of Slovenia Ministry of Health; Ministry of Education, Science and Sport Grants 0381-518, L3-3435 (M.B. and M.P.), P0-503-0103, and Slo-US 2001/34 (A.P.); and the European Union-funded project “Human Transmissible Spongiform Encephalopathies: The Neuropathology Network (PRIONET)” (M.P.). We acknowledge the assistance of Dr. Herbert Budka (Institute of Neurology, University of Vienna, and Austrian Reference Centre for Human Prion Diseases, Vienna, Austria) and Dr. James Ironside (Neuropathology Laboratory, CJD Surveillance Unit, University of Edinburgh, Edinburgh, UK), who kindly provided the samples of GSS and vCJD cerebellar tissue.

  • Correspondence should be addressed to Dr. Mara Bresjanac, Institute of Pathophysiology, Zaloska 4, SI-1000 Ljubljana, Slovenia. E-mail: maja.bresjanac{at}mf.uni-lj.si.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/238029-05$15.00/0

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AbstractFullPdf
Sep 2003318231271
Oct 2003489138
Nov 2003385726
Dec 2003243420
Total 2003428413355
Jan 200437447
Feb 2004223917
Mar 2004334421
Apr 2004263333
May 200417195
Jun 2004374512
Jul 200422377
Aug 200428648
Sep 2004253015
Oct 2004255225
Nov 2004216133
Dec 2004217031
Total 2004314538214
Jan 2005274820
Feb 2005314715
Mar 2005205327
Apr 200593414
May 2005173313
Jun 2005103631
Jul 200593312
Aug 2005142411
Sep 200563931
Oct 2005163612
Nov 2005133318
Dec 2005113315
Total 2005183449219
Jan 200663917
Feb 200683319
Mar 20067379
Apr 200642611
May 200643013
Jun 200652010
Jul 20069209
Aug 200662314
Sep 200643020
Oct 200694116
Nov 200603414
Dec 200656318
Total 200667396170
Jan 200773019
Feb 200752413
Mar 200762719
Apr 200793323
May 200752414
Jun 200771811
Jul 20071126
Aug 200722412
Sep 2007112916
Oct 200773215
Nov 200762913
Dec 20072156
Total 200768297167
Jan 20088209
Feb 200841611
Mar 200883314
Apr 200852413
May 20085185
Jun 2008102212
Jul 200811209
Aug 20086199
Sep 2008261112
Oct 200810299
Nov 200814179
Dec 200861211
Total 2008113241123
Jan 200931513
Feb 200932516
Mar 2009171715
Apr 2009101416
May 200911925
Jun 2009677
Jul 20097139
Aug 2009287
Sep 2009299
Oct 20096822
Nov 2009999
Dec 2009795
Total 200983143153
Jan 20106714
Feb 20102842
Mar 20104531
Apr 201001018
May 20104821
Jun 20105814
Jul 2010529
Aug 2010649
Sep 20106712
Oct 2010697
Nov 201071911
Dec 2010393
Total 20105496191
Jan 2011695
Feb 20115107
Mar 201113158
Apr 20117136
May 20111169
Jun 201181013
Jul 201119511
Aug 20113913
Sep 2011111010
Oct 20111168
Nov 201110213
Dec 20116813
Total 2011110103116
Jan 20125619
Feb 2012478
Mar 2012767
Apr 201210129
May 2012151212
Jun 201213510
Jul 20121289
Aug 20125108
Sep 20128813
Oct 20127311
Nov 201219310
Dec 20122046
Total 201212584122
Jan 2013777
Feb 20131722
Mar 20131448
Apr 20131187
May 2013161111
Jun 2013505
Jul 2013339
Aug 20138310
Sep 20131506
Oct 20131959
Nov 20131624
Dec 201314210
Total 20131454788
Jan 2014649
Feb 20141649
Mar 20141006
Apr 20141611
May 2014245
Jun 2014544
Jul 20144177
Aug 2014829
Sep 201412812
Oct 20143316
Nov 2014232
Dec 20147413
Total 2014915493
Jan 20154910
Feb 20151038
Mar 2015719
Apr 2015114
May 2015421214
Jun 201531311
Jul 2015437
Aug 2015527
Sep 20151345
Oct 2015433
Nov 2015824
Dec 2015344
Total 20151045786
Jan 20166412
Feb 2016349
Mar 201616215
Apr 2016585
May 2016122
Jun 2016685
Jul 20163710
Aug 2016548
Sep 2016527
Oct 2016349
Nov 2016564
Dec 20163814
Total 20166159100
Jan 20171022
Feb 2017156
Mar 20172115
Apr 2017175
May 20173163
Jun 20171105
Jul 2017155
Aug 20173120
Sep 2017043
Oct 2017382
Nov 2017032
Dec 2017083
Total 2017259141
Jan 20181023
Feb 20181104
Mar 2018225
Apr 20184126
May 20188151
Jun 20181122
Jul 20180135
Aug 2018284
Sep 20181192
Oct 20187158
Nov 2018156
Dec 20180113
Total 20183712449
Jan 2019384
Feb 201911210
Mar 20192118
Apr 2019279
May 20192108
Jun 20193116
Jul 2019067
Aug 2019069
Sep 2019248
Oct 2019153
Nov 201931111
Dec 2019266
Total 2019219789
Jan 20200113
Feb 2020331
Mar 2020063
Apr 2020122
May 2020244
Jun 2020513
Jul 2020351
Aug 2020221
Sep 20205129
Oct 2020275
Nov 2020286
Dec 20202108
Total 2020277146
Jan 20211913
Feb 202141310
Mar 20214177
Apr 20210111
May 20212129
Jun 2021190
Jul 20211911
Aug 20213148
Sep 2021396
Oct 20214915
Nov 2021066
Dec 2021274
Total 20212512590
Jan 2022593
Feb 20222123
Mar 202221212
Apr 20223123
May 202211510
Total 2022136031
Total209435452543
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The Journal of Neuroscience: 23 (22)
Journal of Neuroscience
Vol. 23, Issue 22
3 Sep 2003
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Molecular-Imaging Probe 2-(1-{6-[(2-Fluoroethyl)(Methyl) Amino]-2-Naphthyl}Ethylidene) Malononitrile Labels Prion Plaques In Vitro
Mara Bresjanac, Lojze M. Smid, Tomaz D. Vovko, Andrej Petrič, Jorge R. Barrio, Mara Popovic
Journal of Neuroscience 3 September 2003, 23 (22) 8029-8033; DOI: 10.1523/JNEUROSCI.23-22-08029.2003

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Molecular-Imaging Probe 2-(1-{6-[(2-Fluoroethyl)(Methyl) Amino]-2-Naphthyl}Ethylidene) Malononitrile Labels Prion Plaques In Vitro
Mara Bresjanac, Lojze M. Smid, Tomaz D. Vovko, Andrej Petrič, Jorge R. Barrio, Mara Popovic
Journal of Neuroscience 3 September 2003, 23 (22) 8029-8033; DOI: 10.1523/JNEUROSCI.23-22-08029.2003
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Keywords

  • fluorescent labeling
  • human
  • neuroimaging
  • TSE
  • variant Creutzfeldt-Jacob disease
  • amyloid

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