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Cover image
Cover picture: Inositol trisphosphate receptors (IP3Rs,type 1; in green) in the I band of the sarcoplasmic reticulum (cross striations) and in a motor end plate region from dissociated mouse diaphragm muscle. A cluster of nuclei (blue) encircled by membrane of the postsynaptic gutter, marked by alpha-bungarotoxin labeling of acetylcholine receptors (AChR; in red), marks the position of the motor end plate. The overlap of IP3Rs and AChRs leads to the orange tint of the AChR staining. There are some nuclei above the motor end plate region that are surrounded by IP3Rs;these we identify as belonging to muscle satellite cells. A heavily stained cell, which we identify as a Schwann cell, is visible just below the motor end plate. For details, see the article by Powell in this issue (pages 8185–8192).