Cover picture: PS2APP mice develop an age-related cognitive deficit, the histopathological correlate of which is a severe cerebral amyloidosis. A Congo red-stained amyloid plaque in a hemalum-counterstained section of the frontolateral cortex of a 17-month-old transgenic mouse is shown (bright-field optics; 1108 X magnification). For details, see the article by Richards et al. in this issue (pages 8989–9003).