Cellular/Molecular
In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life
John R. Cirrito, Patrick C. May, Mark A. O'Dell, Jennie W. Taylor, Maia Parsadanian, Jeffrey W. Cramer, James E. Audia, Jeffrey S. Nissen, Kelly R. Bales, Steven M. Paul, Ronald B. DeMattos and David M. Holtzman
Journal of Neuroscience 1 October 2003, 23 (26) 8844-8853; DOI: https://doi.org/10.1523/JNEUROSCI.23-26-08844.2003
John R. Cirrito
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Patrick C. May
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Mark A. O'Dell
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Jennie W. Taylor
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Maia Parsadanian
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Jeffrey W. Cramer
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
James E. Audia
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Jeffrey S. Nissen
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Kelly R. Bales
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Steven M. Paul
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
Ronald B. DeMattos
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285
David M. Holtzman
Departments of
1Neurology and
2Molecular Biology and Pharmacology and
3Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110,
4Neuroscience Discovery Research and
5Drug Disposition-Lead Optimization,
6Discovery Chemistry Research, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, and
7Departments of Pharmacology, Toxicology, and Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46285

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In this issue
Journal of Neuroscience
Vol. 23, Issue 26
1 Oct 2003
In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life
John R. Cirrito, Patrick C. May, Mark A. O'Dell, Jennie W. Taylor, Maia Parsadanian, Jeffrey W. Cramer, James E. Audia, Jeffrey S. Nissen, Kelly R. Bales, Steven M. Paul, Ronald B. DeMattos, David M. Holtzman
Journal of Neuroscience 1 October 2003, 23 (26) 8844-8853; DOI: 10.1523/JNEUROSCI.23-26-08844.2003
In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life
John R. Cirrito, Patrick C. May, Mark A. O'Dell, Jennie W. Taylor, Maia Parsadanian, Jeffrey W. Cramer, James E. Audia, Jeffrey S. Nissen, Kelly R. Bales, Steven M. Paul, Ronald B. DeMattos, David M. Holtzman
Journal of Neuroscience 1 October 2003, 23 (26) 8844-8853; DOI: 10.1523/JNEUROSCI.23-26-08844.2003
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