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Behavioral/Systems/Cognitive

Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection

F. Sergio Arana, John A. Parkinson, Elanor Hinton, Anthony J. Holland, Adrian M. Owen and Angela C. Roberts
Journal of Neuroscience 22 October 2003, 23 (29) 9632-9638; https://doi.org/10.1523/JNEUROSCI.23-29-09632.2003
F. Sergio Arana
1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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John A. Parkinson
1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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Elanor Hinton
1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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Anthony J. Holland
1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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Adrian M. Owen
1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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Angela C. Roberts
1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-29-09632.2003
PubMed 
14573543
Published By 
Society for Neuroscience
History 
  • Received June 4, 2003
  • Revision received August 29, 2003
  • Accepted August 29, 2003
  • First published October 22, 2003.
  • Version of record published October 22, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/239632-07.00/0

Author Information

  1. F. Sergio Arana1,
  2. John A. Parkinson1,
  3. Elanor Hinton2,
  4. Anthony J. Holland2,
  5. Adrian M. Owen3, and
  6. Angela C. Roberts1
  1. 1Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, 2Section of Developmental Psychiatry, Department of Psychiatry, Douglas House, Cambridge CB2 2AH, United Kingdom, 3 Medical Research Council Cognition and Brain Unit, Cambridge CB2 2EF, United Kingdom, and The Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
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Author contributions

Disclosures

    • Received June 4, 2003.
    • Revision received August 29, 2003.
    • Accepted August 29, 2003.
  • This work was supported by the Medical Research Council (including a Career Establishment grant to A.C.R.), a Joseph P. O'Hern Scholarship for Travel and Study in Europe sponsored by the Phi Beta Kappa National Honor Society (F.S.A.), a Grindley Fund award, Cambridge, United Kingdom, and a private bequest to the Prader-Willi Association, United Kingdom (E.H.). This is a publication within the Medical Research Council Centre on Behavioral and Clinical Neuroscience. We thank the radiography team at the Wolfson Brain Imaging Centre, Cambridge, United Kingdom.

  • Correspondence should be addressed to Dr. John A Parkinson, Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom. E-mail: jp{at}cartab.net

  • F. Sergio Arana's present address: Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/239632-07$15.00/0

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The Journal of Neuroscience: 23 (29)
Journal of Neuroscience
Vol. 23, Issue 29
22 Oct 2003
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Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection
F. Sergio Arana, John A. Parkinson, Elanor Hinton, Anthony J. Holland, Adrian M. Owen, Angela C. Roberts
Journal of Neuroscience 22 October 2003, 23 (29) 9632-9638; DOI: 10.1523/JNEUROSCI.23-29-09632.2003

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Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection
F. Sergio Arana, John A. Parkinson, Elanor Hinton, Anthony J. Holland, Adrian M. Owen, Angela C. Roberts
Journal of Neuroscience 22 October 2003, 23 (29) 9632-9638; DOI: 10.1523/JNEUROSCI.23-29-09632.2003
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Keywords

  • emotion
  • imaging
  • PET (positron emission tomography)
  • goal-directed action
  • appetitive
  • food preference

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