Cover picture: This color-coded brain image shows the pattern of gray matter loss on the medial surface of the right brain hemisphere in a group of 17 patients with mild to moderate Alzheimer's Disease. Red colors, in paralimbic and cingulate brain regions, denote areas with greatest gray matter loss, whereas cooler colors (yellow and blue) denote minimal or no gray matter loss. These color-coded maps reveal the spatial pattern of deficits in Alzheimer's disease, and they can help understand how the disease progresses in the human brain. For details, see the article by Thompson et al. in this issue (pages 994–1005).