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ARTICLE, CELLULAR/MOLECULAR

Interaction of Calcineurin and Type-A GABA Receptor γ2 Subunits Produces Long-Term Depression at CA1 Inhibitory Synapses

Jian Wang, ShuHong Liu, Ursula Haditsch, WeiHong Tu, Kimberley Cochrane, Gholamreza Ahmadian, Linda Tran, Jadine Paw, YuTian Wang, Isabelle Mansuy, Michael M. Salter and YouMing Lu
Journal of Neuroscience 1 February 2003, 23 (3) 826-836; https://doi.org/10.1523/JNEUROSCI.23-03-00826.2003
Jian Wang
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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ShuHong Liu
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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Ursula Haditsch
2Institute of Cell Biology, Swiss Federal Institute of Technology, CH-8093 Zürich, Switzerland, and Departments of
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WeiHong Tu
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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Kimberley Cochrane
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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Gholamreza Ahmadian
3Pathology and
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Linda Tran
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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Jadine Paw
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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YuTian Wang
3Pathology and
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Isabelle Mansuy
2Institute of Cell Biology, Swiss Federal Institute of Technology, CH-8093 Zürich, Switzerland, and Departments of
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Michael M. Salter
4Physiology, Programme in Brain and Behaviour, Hospital for Sick Children, University of Toronto, Toronto, Canada, M5G 1X8
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YouMing Lu
1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-03-00826.2003
PubMed 
12574411
Published By 
Society for Neuroscience
History 
  • Received August 16, 2002
  • Revision received November 14, 2002
  • Accepted November 15, 2002
  • First published February 1, 2003.
  • Version of record published February 1, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience

Author Information

  1. Jian Wang1,*,
  2. ShuHong Liu1,*,
  3. Ursula Haditsch2,
  4. WeiHong Tu1,
  5. Kimberley Cochrane1,
  6. Gholamreza Ahmadian3,
  7. Linda Tran1,
  8. Jadine Paw1,
  9. YuTian Wang3,
  10. Isabelle Mansuy2,
  11. Michael M. Salter4, and
  12. YouMing Lu1
  1. 1Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1,
  2. 2Institute of Cell Biology, Swiss Federal Institute of Technology, CH-8093 Zürich, Switzerland, and Departments of
  3. 3Pathology and
  4. 4Physiology, Programme in Brain and Behaviour, Hospital for Sick Children, University of Toronto, Toronto, Canada, M5G 1X8
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Author contributions

Disclosures

    • Received August 16, 2002.
    • Revision received November 14, 2002.
    • Accepted November 15, 2002.
  • ↵* J.W. and S.L. contributed equally to this work.

  • This work was supported by the Canadian Institute for Health Research (Y.M.L), Heart and Stroke Foundation, Canada (Y.M.L), Alberta Heritage Foundation for Medical Research (Y.M.L), Canada Foundation for Innovation (Y.M.L), and Alberta Foundation for Innovation and Science (Y.M.L). We thank Dr. Brian Perrino for the construct of CaN420. We thank Drs. John F. MacDonald, Wayne Giles, Keith Sharkey, and Brian MacVicar, for critical comments on this manuscript.

  • Correspondence should be addressed to Dr. YouMing Lu, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1. E-mail: luy{at}ucalgary.ca.

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The Journal of Neuroscience: 23 (3)
Journal of Neuroscience
Vol. 23, Issue 3
1 Feb 2003
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Interaction of Calcineurin and Type-A GABA Receptor γ2 Subunits Produces Long-Term Depression at CA1 Inhibitory Synapses
Jian Wang, ShuHong Liu, Ursula Haditsch, WeiHong Tu, Kimberley Cochrane, Gholamreza Ahmadian, Linda Tran, Jadine Paw, YuTian Wang, Isabelle Mansuy, Michael M. Salter, YouMing Lu
Journal of Neuroscience 1 February 2003, 23 (3) 826-836; DOI: 10.1523/JNEUROSCI.23-03-00826.2003

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Interaction of Calcineurin and Type-A GABA Receptor γ2 Subunits Produces Long-Term Depression at CA1 Inhibitory Synapses
Jian Wang, ShuHong Liu, Ursula Haditsch, WeiHong Tu, Kimberley Cochrane, Gholamreza Ahmadian, Linda Tran, Jadine Paw, YuTian Wang, Isabelle Mansuy, Michael M. Salter, YouMing Lu
Journal of Neuroscience 1 February 2003, 23 (3) 826-836; DOI: 10.1523/JNEUROSCI.23-03-00826.2003
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Keywords

  • GABAA receptors
  • inhibitory synapses
  • plasticity
  • dephosphorylation
  • calcineurin
  • hippocampus

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