How AMPA Receptor Desensitization Depends on Receptor Occupancy

This work was supported by National Institutes of Health Grants GM58926 and NS37874. We thank Mark Mayer for his gift of the two-septa theta glass used in these studies and for useful discussions during the course of this work. We are grateful to Elias Lolis for helping us view the structures of the GluR2 ligand binding core, and Thomas Hughes for his help and the use of his space and equipment.

Correspondence should be addressed to J. R. Howe, Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066. E-mail:james.howe{at}yale.edu.