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Behavioral/Systems/Cognitive

NMDA Currents and Receptor Protein Are Downregulated in the Amygdala during Maintenance of Fear Memory

Fatiha Zinebi, Jiangang Xie, Jie Liu, Rex T. Russell, Joel P. Gallagher, Margaret G. McKernan and Patricia Shinnick-Gallagher
Journal of Neuroscience 12 November 2003, 23 (32) 10283-10291; https://doi.org/10.1523/JNEUROSCI.23-32-10283.2003
Fatiha Zinebi
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Jiangang Xie
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Jie Liu
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Rex T. Russell
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Joel P. Gallagher
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Margaret G. McKernan
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Patricia Shinnick-Gallagher
1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-32-10283.2003
PubMed 
14614087
Published By 
Society for Neuroscience
History 
  • Received June 4, 2003
  • Revision received September 17, 2003
  • Accepted September 19, 2003
  • First published November 12, 2003.
  • Version of record published November 12, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/2310283-09.00/0

Author Information

  1. Fatiha Zinebi1,
  2. Jiangang Xie1,
  3. Jie Liu1,
  4. Rex T. Russell2,
  5. Joel P. Gallagher1,
  6. Margaret G. McKernan3, and
  7. Patricia Shinnick-Gallagher1
  1. 1University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, Texas 77555-1031, 2Department of Anesthesiology, Johns Hopkins University, Baltimore, Maryland 21205, and 3Department of Radiology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157-1088
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Author contributions

Disclosures

    • Received June 4, 2003.
    • Revision received September 17, 2003.
    • Accepted September 19, 2003.
  • This work was supported by National Institutes of Health Grants MH58327 and F30 MH11221. We thank Drs. Geoff Swanson and Jim Blankenship and Brad Schroeder for their helpful comments on this manuscript.

  • Correspondence should be addressed to Dr. Patricia Shinnick-Gallagher, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555-1031. E-mail: psgallag{at}utmb.edu.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/2310283-09$15.00/0

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The Journal of Neuroscience: 23 (32)
Journal of Neuroscience
Vol. 23, Issue 32
12 Nov 2003
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NMDA Currents and Receptor Protein Are Downregulated in the Amygdala during Maintenance of Fear Memory
Fatiha Zinebi, Jiangang Xie, Jie Liu, Rex T. Russell, Joel P. Gallagher, Margaret G. McKernan, Patricia Shinnick-Gallagher
Journal of Neuroscience 12 November 2003, 23 (32) 10283-10291; DOI: 10.1523/JNEUROSCI.23-32-10283.2003

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NMDA Currents and Receptor Protein Are Downregulated in the Amygdala during Maintenance of Fear Memory
Fatiha Zinebi, Jiangang Xie, Jie Liu, Rex T. Russell, Joel P. Gallagher, Margaret G. McKernan, Patricia Shinnick-Gallagher
Journal of Neuroscience 12 November 2003, 23 (32) 10283-10291; DOI: 10.1523/JNEUROSCI.23-32-10283.2003
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Keywords

  • amygdala
  • synaptic plasticity
  • fear conditioning
  • fear-potentiated startle
  • memory
  • learning
  • NR subunits
  • ifenprodil
  • paired-pulse facilitation

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