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Cellular/Molecular

Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction

Georg Köhr, Vidar Jensen, Helmut J. Koester, Andre L. A. Mihaljevic, Jo K. Utvik, Ane Kvello, Ole P. Ottersen, Peter H. Seeburg, Rolf Sprengel and Øivind Hvalby
Journal of Neuroscience 26 November 2003, 23 (34) 10791-10799; https://doi.org/10.1523/JNEUROSCI.23-34-10791.2003
Georg Köhr
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Vidar Jensen
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Helmut J. Koester
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Andre L. A. Mihaljevic
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Jo K. Utvik
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Ane Kvello
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Ole P. Ottersen
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Peter H. Seeburg
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Rolf Sprengel
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Øivind Hvalby
1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-34-10791.2003
PubMed 
14645471
Published By 
Society for Neuroscience
History 
  • Received August 20, 2003
  • Revision received September 12, 2003
  • Accepted September 22, 2003
  • First published November 26, 2003.
  • Version of record published November 26, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience 0270-6474/03/2310791-09.00/0

Author Information

  1. Georg Köhr1,
  2. Vidar Jensen3,
  3. Helmut J. Koester2,
  4. Andre L. A. Mihaljevic1,
  5. Jo K. Utvik4,
  6. Ane Kvello3,
  7. Ole P. Ottersen4,
  8. Peter H. Seeburg1,
  9. Rolf Sprengel1, and
  10. Øivind Hvalby3
  1. 1Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany, 2Baylor College of Medicine, Houston, Texas 77030, and 3Institute of Basic Medical Sciences and 4Centre for Molecular Biology and Neuroscience and Department of Anatomy, University of Oslo, N-0317 Oslo, Norway
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Author contributions

Disclosures

    • Received August 20, 2003.
    • Revision received September 12, 2003.
    • Accepted September 22, 2003.
  • This work was supported in part by Deutsche Forschungsgemeinschaft Grant Ko 1064, the Norwegian Research Council, European Cooperation in Scientific and Technological Research, and European Union Biomed projects QLG3-CT-2001-02089 and QLRT-1999-01022. We thank Prof. P. Andersen and Dr. P. Osten for critically reading this manuscript, Prof. F. M. S. Haug for help with EM quantifications, and Prof. P. Laake with statistics.

  • Correspondence should be addressed to Dr. Georg Köhr, Department of Molecular Neurobiology, Max-Planck-Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany. E-mail: kohr{at}mpimf-heidelberg.mpg.de.

  • Copyright © 2003 Society for Neuroscience 0270-6474/03/2310791-09$15.00/0

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The Journal of Neuroscience: 23 (34)
Journal of Neuroscience
Vol. 23, Issue 34
26 Nov 2003
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Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction
Georg Köhr, Vidar Jensen, Helmut J. Koester, Andre L. A. Mihaljevic, Jo K. Utvik, Ane Kvello, Ole P. Ottersen, Peter H. Seeburg, Rolf Sprengel, Øivind Hvalby
Journal of Neuroscience 26 November 2003, 23 (34) 10791-10799; DOI: 10.1523/JNEUROSCI.23-34-10791.2003

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Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction
Georg Köhr, Vidar Jensen, Helmut J. Koester, Andre L. A. Mihaljevic, Jo K. Utvik, Ane Kvello, Ole P. Ottersen, Peter H. Seeburg, Rolf Sprengel, Øivind Hvalby
Journal of Neuroscience 26 November 2003, 23 (34) 10791-10799; DOI: 10.1523/JNEUROSCI.23-34-10791.2003
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Keywords

  • gene-targeted mouse
  • hippocampal CA3-to-CA1 LTP
  • postembedding immunogold labeling
  • coimmunoprecipitation
  • NR2B antagonists
  • two-photon imaging
  • spinous calcium transients
  • signal transduction

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