In the article “Individual Properties of the Two Functional Agonist Sites in GABAA Receptors,” by Sabine W. Baumann, Roland Baur, and Erwin Sigel, which appeared on pages 11158-11166 of the December 3, 2003 issue, several equations were set incorrectly because of a printer's error. The errors are located on page 11159, right column, beginning on lines 15 and 50, respectively. For the equation starting on line 15, the correct version is as follows:
“loose subunits, I(c) = [100 · (1 + L)]/[(1/{1 + (L1 · K1)/(L2 · K2) + (L1 · c)/(L · K2)}) · (1 + {K1 · L1}/c + L1 + {L1 · K1}/K2 + {c · L1}/K2 + {L1 · K1}/{L2 · K2} + {c · L1}/{K2 · L})]; for receptors linked αβα/γβ, I(c) = [100 · (1 + fA · L)]/[(1/{1 + (L1 · K1)/(L2 · K2) + (fa · L1 · c)/(fA · L · K2)}) · (1 + {K1 · fa · L1}/c + fa · L1 + {fa · L1 · K1}/K2 + {c · fa · L1}/K2 + {L1 · K1}/{L2 · K2} + {c · fa · L1}/{K2 · fA · L})]; for receptors linked γβα/βα, I(c) = [100 · (1 + fG · L)]/[(1/{1 + (L1 · K1)/(L2 · K2) + (fg · L1 · c)/(fG · L · K2)}) · (1 + {K1 · fg · L1}/c + fg · L1 + {fg · L1 · K1}/K2 + {c · fg · L1}/K2 + {L1 · K1}/{L2 · K2} + {c · fg · L1}/{K2 · fG · L})]; for αβα/γβ receptors mutated in site 1 and an analogous equation for the mutation in residue α165 in site 1, I(c) = [100 · (1 + fA · L)]/[(1/{1 + (L1 · K1205)/(L2 · ta205 · K2) + (fa · L1 · c)/(fA · L · ta205 · K2)}) · (1 + {K1205 · fa · L1}/c + fa · L1 + {fa · L1 · K1205}/{ta205 · K2} + {c · fa · L1}/{ta205 · K2} + {L1 · K1205}/{L2 · ta205 · K2} + {fa · L1 · c}/{fA · L · ta205 · K2})]; for αβα/γβ receptors mutated in site 2 and an analogous equation for the mutation in residue α165 in site 2, I(c) = [100 · (1 + fA · L)]/[(1/{1 + (L1 · ta205 · K1)/(L2 · K2205) + (fa · L1 · c)/(fA · L · K2205)}) · (1 + {ta205 · K1 · fa · L1}/c + fa · L1 + {fa · L1 · ta205 · K1}/K2205 + {c · fa · L1}/K2205 + {L1 · ta205 · K1}/{L2 · K2205} + {fa · L1 · c}/{fA · L · K2205})]; and for γβα/βα receptors mutated in both sites, I(c) = [100 · (1 + fG · L)]/[(1/{1 + (L1 · K165)/(L2 · K265) + (fg · L1 · c)/(fG · L · ta65 · K265)}) · (1 + {ta65 · K165 · fg · L1}/c + fg · L1 + {fg · L1 · K165}/K265 + {c · fg · L1}/{t65 · K265} + {L1 · K165}/{L2 · K265} + {c · fg · L1}/{ta65 · K265 · fG · L})]; I is the current, K1 and K2 are dissociation constants for agonists of the unmutated and K165,.... ”
For the equation starting on line 50, the correct version is as follows:
“Inhibition was fitted with the equation I(c) = Imax /[(1/{1 + (L1 · K1)/(L2 · K2) + (L1 · c)/(L · K2)}) · (1 + {K1 · L1}/c + L1 + {L1 · K1}/K2 + {c · L1}/K2 + {L1 · K1}/{L2 · K2} + {c · L1}/{K2 · L} + {(b · K1 · L1)/c} · {1/K1i + 1/K2i + b/(K1i · K2i)})] for loose subunits, I(c) = Imax /[(1/{1 + (L1 · K1205)/(L2 · ta205 · K2) + (fa · L1 · c)/(fA · L · ta205 · K2)}) · (1 + {K1205 · fa · L1}/c + fa · L1 + {fa · L1 · K1205}/{ta205 · K2} + {c · fa · L1}/{ta205 · K2} + {L1 · K1205}/{L2 · ta205 · K2} + {fa · L1 · c}/{fA · L · ta205 · K2} + {(b · K1 · fa · L1)/c} · {1/(m · K1I) + 1/(tb205 · K2I) + b/(m · K1i · tb205 · K2i)})] for αβα/γβ receptors mutated in site 1,.... ”
