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ARTICLE, Behavioral/Systems/Cognitive

Resiniferatoxin Induces Paradoxical Changes in Thermal and Mechanical Sensitivities in Rats: Mechanism of Action

Hui-Lin Pan, Ghous M. Khan, Kevin D. Alloway and Shao-Rui Chen
Journal of Neuroscience 1 April 2003, 23 (7) 2911-2919; https://doi.org/10.1523/JNEUROSCI.23-07-02911.2003
Hui-Lin Pan
1Departments of Anesthesiology and
2Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850
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Ghous M. Khan
1Departments of Anesthesiology and
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Kevin D. Alloway
2Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850
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Shao-Rui Chen
1Departments of Anesthesiology and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.23-07-02911.2003
PubMed 
12684478
Published By 
Society for Neuroscience
History 
  • Received October 28, 2002
  • Revision received December 12, 2002
  • Accepted January 13, 2003
  • First published April 1, 2003.
  • Version of record published April 1, 2003.
Copyright & Usage 
Copyright © 2003 Society for Neuroscience

Author Information

  1. Hui-Lin Pan1,2,
  2. Ghous M. Khan1,
  3. Kevin D. Alloway2, and
  4. Shao-Rui Chen1
  1. 1Departments of Anesthesiology and
  2. 2Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850
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Author contributions

Disclosures

    • Received October 28, 2002.
    • Revision received December 12, 2002.
    • Accepted January 13, 2003.
  • This work was supported by National Institutes of Health (NIH) Grants GM64830, NS41178, and HL04199. H.-L.P was a recipient of an Independent Scientist Award supported by NIH during the course of this study. We are grateful to Pamela Myers for her secretarial assistance and to Roland Myers for his technical support.

  • Correspondence should be addressed to Dr. Hui-Lin Pan, Department of Anesthesiology, H187, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033. E-mail:hpan{at}psu.edu.

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The Journal of Neuroscience: 23 (7)
Journal of Neuroscience
Vol. 23, Issue 7
1 Apr 2003
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Resiniferatoxin Induces Paradoxical Changes in Thermal and Mechanical Sensitivities in Rats: Mechanism of Action
Hui-Lin Pan, Ghous M. Khan, Kevin D. Alloway, Shao-Rui Chen
Journal of Neuroscience 1 April 2003, 23 (7) 2911-2919; DOI: 10.1523/JNEUROSCI.23-07-02911.2003

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Resiniferatoxin Induces Paradoxical Changes in Thermal and Mechanical Sensitivities in Rats: Mechanism of Action
Hui-Lin Pan, Ghous M. Khan, Kevin D. Alloway, Shao-Rui Chen
Journal of Neuroscience 1 April 2003, 23 (7) 2911-2919; DOI: 10.1523/JNEUROSCI.23-07-02911.2003
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Keywords

  • neuropathic pain
  • postherpetic neuralgia
  • capsaicin
  • VR1 receptor
  • TRPV channel
  • spinal cord dorsal horn
  • axonal sprouting

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