Article Figures & Data
Figures
- Fig. 1.
GluRA−/− mice make more spatial reference and working memory errors during acquisition of a radial-maze task in which the same three of six arms were always baited but in which the food rewards were not replaced within a trial. The mean ± SEM number of RM errors (A), WM-C errors (B), and WM-I errors (C) for wild-type (WT; white circles) and GluRA−/− (black circles) mice during six blocks of training (4 trials per block) is shown. Where error bars appear absent, the error is too small to be visible.
- Fig. 2.
GluRA−/− mice show normal spatial reference memory performance on a three-from-six radial-maze task in which doors prevent mice from making working memory errors during the acquisition phase. The mean ± SEM number of RM errors is shown for wild-type (WT; white circles) and GluRA−/− (black circles) mice during six blocks of training in which doors prevented mice from making working memory errors (Acquisition; 4 trials per block) (left), three blocks of spatial reference memory retention testing after a 10 d interval with doors still preventing WM errors (Retention; 4 trials per block) (center), and a final two blocks of testing during which the doors were then no longer used to prevent working memory errors (RM/WM; 4 trials per block) (right). Where error bars appear absent, the error is too small to be visible.
- Fig. 3.
GluRA−/− mice display a robust spatial working memory impairment in the absence of a lasting spatial reference memory impairment on the three-from-six radial-maze task in which the doors were now no longer used to prevent working memory errors (see also Fig. 2, right). The mean ± SEM number of WM-C errors for wild-type (WT; white circles) and GluRA−/− mice (black circles) is shown during two blocks of testing (RM/WM; 4 trials per block). Where error bars appear absent, the error is too small to be visible.
- Fig. 4.
C57BL/6J mice with cytotoxic HPC lesions show a spatial reference memory impairment on a three-from-six radial-maze task in which doors prevent mice from making working memory errors during the acquisition phase. The mean ± SEM number of RM errors is shown for sham (white circles) and hippocampal-lesioned (white squares) mice during six blocks of training in which doors prevented mice from making working memory errors (4 trials per block). Where error bars appear absent, the error is too small to be visible.
