Figure 1.
FGL enhances memory for context. a, b, In a ConFC test, rats received footshocks in the conditioning chamber and were injected intracerebroventricularly with 5 μg of the FGL peptide (n = 11), vehicle (n = 18), or control peptide FGLala (n = 10) immediately after the conditioning session. They were tested in the conditioning chamber 24 hr, 1 week, and 1 month later. Data from vehicle and FGLala groups are merged into a single control group (a), because no difference was observed (b) between them. c,d, In a CueFC test, rats received pairings of tone and footshocks in the conditioning chamber. They were injected intracerebroventricularly with 5 μg of the FGL peptide (n = 6) or vehicle (n = 6) immediately after the conditioning session. They were tested in a different chamber in the presence of a tone 24 hr, 1 week, and 28 d later (c) or in the original conditioning chamber in the absence of a tone 1 month later (d). Data are mean percentage of time spent freezing ± SEM; *p < 0.05, **p < 0.01, and ***p < 0.005, when compared with control group.