Dysregulated IP₃ Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation in Presenilin1 Results in Exaggerated Ca²⁺ Signals and Altered Membrane Excitability

This work was supported by National Institutes of Health Grants GM48071, AG17968, and AG16573. We thank Imithri De Silva for assistance in data analysis and manuscript preparation, and Dr. Frank Wujtack for the gift of the SERCA 2b primary antibody.

Correspondence should be addressed to Grace E. Stutzmann, Department of Neurobiology and Behavior, University of California, Irvine, McGaugh Hall 1146, Irvine, CA 92697-4550. E-mail: grace{at}uci.edu.

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