Figure 1.
ChAT and AChE activity in Chat heterozygotes. a, ChAT activity is reduced in Chat+/- brain regions. In each of several regions of the brain (FCTX, frontal cortex; PCTX, parietal cortex; SPT, septum; STR, striatum; OB, olfactory bulb; HPC, hippocampus), ChAT activity (nmol/mg of protein/min) was reduced by almost half (FCTX, 41%; PCTX, 36%; HPC, 40%; SPT, 49%; STR, 42%; OB, 43%). Error bars represent SEM. Significant differences were observed between Chat+/+ mice and Chat+/- mice in all brain regions examined (FCTX, p < 0.0001; PCTX, p < 0.0005; HPC, p < 0.001; SPT, p < 0.001; STR, p < 0.005; OB, p < 0.0001). b, AChE activity in various brain regions of Chat+/+ and Chat+/- mice. No significant effect of genotype was found in any brain region.