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Behavioral/Systems/Cognitive

Synaptic Contributions to Focal and Widespread Spatiotemporal Dynamics in the Isolated Rat Subiculum In Vitro

L. Menendez de la Prida and B. Gal
Journal of Neuroscience 16 June 2004, 24 (24) 5525-5536; DOI: https://doi.org/10.1523/JNEUROSCI.0309-04.2004
L. Menendez de la Prida
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B. Gal
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Abstract

The subiculum, which has a strategic position in controlling hippocampal activity, is receiving significant attention in epilepsy research. However, the functional organization of subicular circuits remains unknown. Here, we combined different recording and analytical methods to study focal and widespread population activity in the isolated subiculum in zero Mg2+ media. Patch and field recordings were combined to examine the contribution of different cell types to population activity. The properties of cells leading field activity were examined. Predictive factors for a cell to behave as leader included exhibiting the bursting phenotype, displaying a low firing threshold, and having more distal apical dendrites. A subset of bursting cells constituted the first glutamatergic type that led a recruitment process that subsequently activated additional excitatory as well as inhibitory cells. This defined a sequence of synaptic excitation and inhibition that was studied by measuring the associated conductance changes and the evolution of the composite reversal potential. It is shown that inhibition was time-locked to excitation, which shunted excitatory inputs and suppressed firing during focal activity. This was recorded extracellularly as a multi-unit ensemble of active cells, the spatial boundaries of which were controlled by inhibition in contrast to widespread epileptiform activity. Focal activity was not dependent on the preparation or the developmental state because it was also recorded under 5 mm [K+]o and in adult tissue. Our data indicate that the subicular networks can be spontaneously organized as leader-follower local circuits in which excitation is mainly driven by a subset of bursting cells and inhibition controls spatiotemporal firing.

  • hippocampus
  • subiculum
  • epilepsy
  • conductance
  • shunting inhibition
  • slices
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The Journal of Neuroscience: 24 (24)
Journal of Neuroscience
Vol. 24, Issue 24
16 Jun 2004
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Synaptic Contributions to Focal and Widespread Spatiotemporal Dynamics in the Isolated Rat Subiculum In Vitro
L. Menendez de la Prida, B. Gal
Journal of Neuroscience 16 June 2004, 24 (24) 5525-5536; DOI: 10.1523/JNEUROSCI.0309-04.2004

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Synaptic Contributions to Focal and Widespread Spatiotemporal Dynamics in the Isolated Rat Subiculum In Vitro
L. Menendez de la Prida, B. Gal
Journal of Neuroscience 16 June 2004, 24 (24) 5525-5536; DOI: 10.1523/JNEUROSCI.0309-04.2004
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More in this TOC Section

  • Gravin Orchestrates Protein Kinase A and β2-Adrenergic Receptor Signaling Critical for Synaptic Plasticity and Memory
  • Generation of Intensity Selectivity by Differential Synaptic Tuning: Fast-Saturating Excitation But Slow-Saturating Inhibition
  • Episodic Reinstatement in the Medial Temporal Lobe
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