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Cellular/Molecular

Gain and Loss of Channel Function by Alanine Substitutions in the Transmembrane Segments of the Rat ATP-Gated P2X2 Receptor

Zhiyuan Li, Keisuke Migita, Damien S. K. Samways, Mark M. Voigt and Terrance M. Egan
Journal of Neuroscience 18 August 2004, 24 (33) 7378-7386; https://doi.org/10.1523/JNEUROSCI.1423-04.2004
Zhiyuan Li
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Keisuke Migita
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Damien S. K. Samways
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Mark M. Voigt
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Terrance M. Egan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1423-04.2004
PubMed 
15317863
Published By 
Society for Neuroscience
History 
  • Received April 15, 2004
  • Revision received June 8, 2004
  • Accepted June 15, 2004
  • First published August 24, 2004.
  • Version of record published August 24, 2004.
Copyright & Usage 
Copyright © 2004 Society for Neuroscience 0270-6474/04/247378-09.00/0

Author Information

  1. Zhiyuan Li,
  2. Keisuke Migita,
  3. Damien S. K. Samways,
  4. Mark M. Voigt, and
  5. Terrance M. Egan
  1. Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri 63104
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Author contributions

Disclosures

    • Received April 15, 2004.
    • Revision received June 8, 2004.
    • Accepted June 15, 2004.
  • This work was supported by the National Institutes of Health. We thank Angela Lipka for help with tissue culture and transfections, Mary Ellsworth for measuring the concentration of ATP in the medium, and Baljit Singh Khakh and Graeme Henderson for reviewing this manuscript. The cDNA encoding P2X2-YFP was a gift from Dr. Baljit Singh Khakh (Medical Research Council Laboratory of Molecular Biology, Cambridge, UK).

  • Correspondence should be addressed to Dr. Terrance M. Egan, Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104. E-mail: egantm{at}slu.edu.

  • K. Migita's present address: Department of Pharmacology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jounan-ku Fukuoka, Fukuoka 814-0180, Japan.

  • Copyright © 2004 Society for Neuroscience 0270-6474/04/249378-•$15.00/0

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The Journal of Neuroscience: 24 (33)
Journal of Neuroscience
Vol. 24, Issue 33
18 Aug 2004
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Gain and Loss of Channel Function by Alanine Substitutions in the Transmembrane Segments of the Rat ATP-Gated P2X2 Receptor
Zhiyuan Li, Keisuke Migita, Damien S. K. Samways, Mark M. Voigt, Terrance M. Egan
Journal of Neuroscience 18 August 2004, 24 (33) 7378-7386; DOI: 10.1523/JNEUROSCI.1423-04.2004

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Gain and Loss of Channel Function by Alanine Substitutions in the Transmembrane Segments of the Rat ATP-Gated P2X2 Receptor
Zhiyuan Li, Keisuke Migita, Damien S. K. Samways, Mark M. Voigt, Terrance M. Egan
Journal of Neuroscience 18 August 2004, 24 (33) 7378-7386; DOI: 10.1523/JNEUROSCI.1423-04.2004
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