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Featured ArticleNeurobiology of Disease

Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

Thor D. Stein, Nicholas J. Anders, Charles DeCarli, Sic L. Chan, Mark P. Mattson and Jeffrey A. Johnson
Journal of Neuroscience 1 September 2004, 24 (35) 7707-7717; https://doi.org/10.1523/JNEUROSCI.2211-04.2004
Thor D. Stein
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Nicholas J. Anders
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Charles DeCarli
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Sic L. Chan
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Mark P. Mattson
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Jeffrey A. Johnson
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2211-04.2004
PubMed 
15342738
Published By 
Society for Neuroscience
History 
  • Received June 7, 2004
  • Revision received July 16, 2004
  • Accepted July 18, 2004
  • First published September 1, 2004.
  • Version of record published September 1, 2004.
Copyright & Usage 
Copyright © 2004 Society for Neuroscience 0270-6474/04/247707-11.00/0

Author Information

  1. Thor D. Stein1,
  2. Nicholas J. Anders2,
  3. Charles DeCarli5,
  4. Sic L. Chan6,
  5. Mark P. Mattson6, and
  6. Jeffrey A. Johnson1,2,3,4
  1. 1Neuroscience Training Program, 2School of Pharmacy, 3Environmental Toxicology Center, and 4Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, 5Department of Neurology and Center for Neuroscience, University of California Davis, Sacramento, California 95817, and 6Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224
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Author contributions

Disclosures

    • Received June 7, 2004.
    • Revision received July 16, 2004.
    • Accepted July 18, 2004.
  • This work was supported by National Institute of Environmental Health Sciences Grants ES08089 (J.A.J.), ES10042 (J.A.J.), and P30 AG10129 (C.D.) and by the Wisconsin Distinguished Rath Graduate Fellowship in Medicine (T.D.S.). We thank Karen Hsiao Ashe for providing Tg2576 mice, the W. M. Keck Laboratory for Biological Imaging (University of Wisconsin) for use of the laser scanning confocal system, and Matthew Slattery and the Molecular Biology Core Facility (University of Wisconsin Environmental Health Science Center) for conducting the gene array hybridizations.

  • Correspondence should be addressed to Jeffrey A. Johnson, University of Wisconsin-Madison, School of Pharmacy, 6125 Rennebohm Hall, 777 Highland Avenue, Madison, WI 53705-2222. E-mail: jajohnson{at}pharmacy.wisc.edu.

  • Copyright © 2004 Society for Neuroscience 0270-6474/04/247707-11$15.00/0

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Jan 201863238
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Mar 201862815
Apr 20183317
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Jul 201843012
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Sep 201812512
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Feb 20191205
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Apr 2019103315
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May 2020133123
Jun 202021711
Jul 2020293
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Oct 202062626
Nov 202063220
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Total 202066221127
Jan 202194615
Feb 202163012
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Apr 2021163427
May 2021112212
Jun 20214162
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Apr 202513812
May 202573512
Jun 2025103914
Jul 20256366
Aug 202563828
Sep 202575416
Oct 202565221
Nov 202577024
Dec 2025251
Total 202577502177
Total60427111211
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The Journal of Neuroscience: 24 (35)
Journal of Neuroscience
Vol. 24, Issue 35
1 Sep 2004
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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
Thor D. Stein, Nicholas J. Anders, Charles DeCarli, Sic L. Chan, Mark P. Mattson, Jeffrey A. Johnson
Journal of Neuroscience 1 September 2004, 24 (35) 7707-7717; DOI: 10.1523/JNEUROSCI.2211-04.2004

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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
Thor D. Stein, Nicholas J. Anders, Charles DeCarli, Sic L. Chan, Mark P. Mattson, Jeffrey A. Johnson
Journal of Neuroscience 1 September 2004, 24 (35) 7707-7717; DOI: 10.1523/JNEUROSCI.2211-04.2004
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