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Featured ArticleNeurobiology of Disease

Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

Thor D. Stein, Nicholas J. Anders, Charles DeCarli, Sic L. Chan, Mark P. Mattson and Jeffrey A. Johnson
Journal of Neuroscience 1 September 2004, 24 (35) 7707-7717; DOI: https://doi.org/10.1523/JNEUROSCI.2211-04.2004
Thor D. Stein
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Nicholas J. Anders
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Charles DeCarli
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Sic L. Chan
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Mark P. Mattson
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Jeffrey A. Johnson
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2211-04.2004
PubMed 
15342738
Published By 
Society for Neuroscience
History 
  • Received June 7, 2004
  • Revision received July 16, 2004
  • Accepted July 18, 2004
  • First published September 1, 2004.
  • Version of record published September 1, 2004.
Copyright & Usage 
Copyright © 2004 Society for Neuroscience 0270-6474/04/247707-11.00/0

Author Information

  1. Thor D. Stein1,
  2. Nicholas J. Anders2,
  3. Charles DeCarli5,
  4. Sic L. Chan6,
  5. Mark P. Mattson6, and
  6. Jeffrey A. Johnson1,2,3,4
  1. 1Neuroscience Training Program, 2School of Pharmacy, 3Environmental Toxicology Center, and 4Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, 5Department of Neurology and Center for Neuroscience, University of California Davis, Sacramento, California 95817, and 6Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224
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Author contributions

Disclosures

    • Received June 7, 2004.
    • Revision received July 16, 2004.
    • Accepted July 18, 2004.
  • This work was supported by National Institute of Environmental Health Sciences Grants ES08089 (J.A.J.), ES10042 (J.A.J.), and P30 AG10129 (C.D.) and by the Wisconsin Distinguished Rath Graduate Fellowship in Medicine (T.D.S.). We thank Karen Hsiao Ashe for providing Tg2576 mice, the W. M. Keck Laboratory for Biological Imaging (University of Wisconsin) for use of the laser scanning confocal system, and Matthew Slattery and the Molecular Biology Core Facility (University of Wisconsin Environmental Health Science Center) for conducting the gene array hybridizations.

  • Correspondence should be addressed to Jeffrey A. Johnson, University of Wisconsin-Madison, School of Pharmacy, 6125 Rennebohm Hall, 777 Highland Avenue, Madison, WI 53705-2222. E-mail: jajohnson{at}pharmacy.wisc.edu.

  • Copyright © 2004 Society for Neuroscience 0270-6474/04/247707-11$15.00/0

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Article usage: September 2004 to April 2021

AbstractFullPdf
Sep 20048276971143
Oct 200459287252
Nov 200456179170
Dec 20045211870
Total 200499412811635
Jan 20054512770
Feb 20053410581
Mar 20055312672
Apr 200526150110
May 200517159120
Jun 20051912661
Jul 20051510756
Aug 2005218456
Sep 20051110391
Oct 20051610773
Nov 2005159182
Dec 20051112275
Total 20052831407947
Jan 2006119978
Feb 200688466
Mar 200668264
Apr 2006116766
May 200658567
Jun 200686053
Jul 200665847
Aug 200676037
Sep 2006167849
Oct 2006137350
Nov 2006138366
Dec 2006114039
Total 2006115869682
Jan 2007114937
Feb 2007104650
Mar 2007206761
Apr 2007184837
May 2007116956
Jun 2007105324
Jul 2007113934
Aug 2007103826
Sep 2007102825
Oct 2007174136
Nov 200783446
Dec 200784149
Total 2007144553481
Jan 2008153135
Feb 2008103132
Mar 2008254644
Apr 2008333637
May 2008234133
Jun 2008145440
Jul 2008392428
Aug 2008803723
Sep 2008953131
Oct 2008602722
Nov 2008543119
Dec 200831818
Total 2008451407362
Jan 2009263231
Feb 2009162823
Mar 2009624740
Apr 2009303322
May 2009154131
Jun 2009304824
Jul 2009202922
Aug 2009122316
Sep 2009293730
Oct 2009532521
Nov 2009504136
Dec 20091352250
Total 2009478406346
Jan 2010543553
Feb 2010202744
Mar 2010203338
Apr 2010204634
May 201016169
Jun 201072018
Jul 201082710
Aug 2010203519
Sep 2010112325
Oct 2010123330
Nov 2010183924
Dec 201093026
Total 2010215364330
Jan 2011252118
Feb 201172220
Mar 2011312327
Apr 2011154639
May 2011182724
Jun 2011261922
Jul 2011102523
Aug 2011272317
Sep 2011222118
Oct 2011183623
Nov 2011223328
Dec 2011242618
Total 2011245322277
Jan 2012162219
Feb 2012221322
Mar 2012182418
Apr 2012322227
May 2012222721
Jun 2012131617
Jul 2012172618
Aug 2012151817
Sep 201219912
Oct 2012231820
Nov 2012342226
Dec 20122979
Total 2012260224226
Jan 2013253328
Feb 2013271918
Mar 2013292224
Apr 2013202242
May 2013312629
Jun 201314722
Jul 201371824
Aug 2013171823
Sep 201319919
Oct 2013182218
Nov 2013232635
Dec 2013275998
Total 2013257281380
Jan 2014243168
Feb 2014113951
Mar 2014242233
Apr 2014321324
May 2014312731
Jun 2014372117
Jul 2014384830
Aug 2014121927
Sep 2014401421
Oct 2014251612
Nov 201422229
Dec 201429108
Total 2014325282331
Jan 2015285414
Feb 201581114
Mar 201514429
Apr 2015141414
May 201592317
Jun 2015142816
Jul 2015162111
Aug 2015182320
Sep 2015201311
Oct 201521109
Nov 2015251913
Dec 201518157
Total 2015205273155
Jan 201615245
Feb 201626229
Mar 201623348
Apr 201623343
May 2016234315
Jun 201610259
Jul 2016101211
Aug 201611238
Sep 2016141310
Oct 2016171920
Nov 2016193436
Dec 201662327
Total 2016197306161
Jan 20175485
Feb 20177469
Mar 20175379
Apr 20177147
May 201718525
Jun 2017132910
Jul 20177197
Aug 20175225
Sep 20178217
Oct 20170268
Nov 201784324
Dec 20173328
Total 201786389104
Jan 201863238
Feb 20184226
Mar 201862815
Apr 20183317
May 201853821
Jun 201883616
Jul 201843012
Aug 201893717
Sep 201812512
Oct 201852716
Nov 201842710
Dec 201883312
Total 201863366182
Jan 201962612
Feb 20191205
Mar 2019112810
Apr 2019103315
May 2019162210
Jun 201953711
Jul 201982016
Aug 201951714
Sep 201971910
Oct 2019172211
Nov 2019131511
Dec 201921711
Total 2019101276136
Jan 20209186
Feb 20209123
Mar 20205147
Apr 2020131711
May 2020133123
Jun 202021711
Jul 2020293
Aug 20201125
Sep 202042212
Oct 202062626
Nov 202063220
Dec 202092811
Total 202079238138
Jan 202194615
Feb 202163012
Mar 202174419
Apr 202191619
Total 20213113665
Total452983806938
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The Journal of Neuroscience: 24 (35)
Journal of Neuroscience
Vol. 24, Issue 35
1 Sep 2004
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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
Thor D. Stein, Nicholas J. Anders, Charles DeCarli, Sic L. Chan, Mark P. Mattson, Jeffrey A. Johnson
Journal of Neuroscience 1 September 2004, 24 (35) 7707-7717; DOI: 10.1523/JNEUROSCI.2211-04.2004

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Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
Thor D. Stein, Nicholas J. Anders, Charles DeCarli, Sic L. Chan, Mark P. Mattson, Jeffrey A. Johnson
Journal of Neuroscience 1 September 2004, 24 (35) 7707-7717; DOI: 10.1523/JNEUROSCI.2211-04.2004
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