Failed Clearance of Aneuploid Embryonic Neural Progenitor Cells Leads to Excess Aneuploidy in the Atm-Deficient But Not the Trp53-Deficient Adult Cerebral Cortex

This work was supported by the National Institute of Neurological Disorders and Stroke, V Foundation, and Searle Scholars Program (C.B.); the National Institute of Mental Health, Helen L. Dorris Child and Adolescent Neural and Psychiatric Disorder Institute, and an unrestricted gift from Merck Research Laboratories (J.C.); predoctoral support from a National Institute of General Medical Sciences Pharmacology training grant (M.J.M. and A.H.Y.) and the National Science Foundation (D.K.); postdoctoral support from the PEW Latin American Fellows (S.K.R.); and a Neuroplasticity of Aging Training grant (M.A.K.). We are grateful to Dr. H. L. Borges for critical reading of this manuscript and to F. He and the University of California, San Diego Biostatistics and Informatics Consulting Laboratory for assistance with statistical tests. We thank Dr. F. H. Gage for helpful advice and Dr. H. L. Borges, M. Hemming, G. Kennedy, M. Fontanoz, and D. Mitchell for technical assistance.

Correspondence should be addressed to Dr. Carrolee Barlow, The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037. E-mail: barlow{at}salk.edu.

D. Kaushal's present address: Howard Hughes Medical Institute, The Children's Hospital, Boston, MA 02446.

M. J. McConnell, A. H. Yang, M. A. Kingbury, S. K. Rehen, and J. Chun's current address: Department of Molecular Biology and Helen L. Dorris Institute, The Scripps Research Institute, La Jolla, CA 92037.

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