β1 Integrins in Muscle, But Not in Motor Neurons, Are Required for Skeletal Muscle Innervation

Martin Schwander; Ryuichi Shirasaki; Samuel L. Pfaff; Ulrich Müller

doi:10.1523/JNEUROSCI.1345-04.2004

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.1345-04.2004

PubMed

15371519

Published By

Society for Neuroscience

History

Received April 9, 2004
Revision received July 15, 2004
Accepted July 27, 2004
First published September 15, 2004.

Version of record published September 15, 2004.

Author Information

Martin Schwander1,
Ryuichi Shirasaki2,
Samuel L. Pfaff2, and
Ulrich Müller1

¹Department of Cell Biology and Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, and ²Gene Expression Laboratory, The Salk Institute, La Jolla, California 92037

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Author contributions

Disclosures

Received April 9, 2004.
Revision received July 15, 2004.
Accepted July 27, 2004.

This research was funded by the Novartis Research Foundation(U.M.), the Schweizer Stiftung zur Erforschung der Muskelkrankheiten (U.M. and M.S.), Japan Society for the Promotion of Science Fellowship for Research Abroad (R.S.), and National Institutes of Health Grants 1RO1 NS046456 (U.M.) and 5RO1 NS037116 (S.L.P.). We thank S. C. Froehner, U. Mayer, and M. Ruegg for their kind gift of antibodies; M. Ruegg for recombinant agrin; S. Orkin for Rosa26lacZ^flox mice; C. Damsky for Itgb1^+/- mice; R. Klein for nestin-Cre mice; and D. Graus-Porta and M. Senften for their contribution in the analysis of nestin-Cre mice.
Correspondence should be addressed to U. Müller, The Scripps Research Institute, Department of Cell Biology, 10550 North Torrey Pines Road, La Jolla, CA 92073. E-mail: umueller{at}scripps.edu.
Copyright © 2004 Society for Neuroscience 0270-6474/04/248181-11$15.00/0

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	Abstract	Full	Pdf
Sep 2004	432	269	394
Oct 2004	61	152	92
Nov 2004	35	86	54
Dec 2004	30	53	38
Total 2004	558	560	578
Jan 2005	23	72	61
Feb 2005	21	55	30
Mar 2005	20	42	21
Apr 2005	13	77	26
May 2005	6	56	31
Jun 2005	20	68	25
Jul 2005	5	49	23
Aug 2005	7	39	20
Sep 2005	5	53	21
Oct 2005	4	42	29
Nov 2005	9	51	31
Dec 2005	12	33	15
Total 2005	145	637	333
Jan 2006	4	25	11
Feb 2006	4	40	18
Mar 2006	4	38	27
Apr 2006	0	18	11
May 2006	3	37	19
Jun 2006	5	28	15
Jul 2006	5	26	7
Aug 2006	1	22	7
Sep 2006	4	35	22
Oct 2006	8	29	13
Nov 2006	7	36	15
Dec 2006	1	25	6
Total 2006	46	359	171
Jan 2007	8	35	18
Feb 2007	4	26	16
Mar 2007	2	28	19
Apr 2007	3	21	10
May 2007	3	22	12
Jun 2007	6	20	10
Jul 2007	5	21	17
Aug 2007	2	21	7
Sep 2007	5	16	4
Oct 2007	8	22	12
Nov 2007	5	22	15
Dec 2007	7	14	4
Total 2007	58	268	144
Jan 2008	5	30	12
Feb 2008	7	17	10
Mar 2008	18	19	19
Apr 2008	13	17	12
May 2008	11	9	14
Jun 2008	12	22	15
Jul 2008	20	33	19
Aug 2008	21	16	8
Sep 2008	58	13	10
Oct 2008	35	12	1
Nov 2008	20	13	8
Dec 2008	6	35	5
Total 2008	226	236	133
Jan 2009	6	15	13
Feb 2009	12	20	7
Mar 2009	20	17	7
Apr 2009	6	19	12
May 2009	2	16	13
Jun 2009	4	15	8
Jul 2009	8	22	8
Aug 2009	4	14	2
Sep 2009	5	15	7
Oct 2009	8	11	1
Nov 2009	11	7	8
Dec 2009	20	16	6
Total 2009	106	187	92
Jan 2010	5	17	7
Feb 2010	6	35	12
Mar 2010	15	12	10
Apr 2010	6	17	8
May 2010	4	27	6
Jun 2010	2	18	14
Jul 2010	2	22	5
Aug 2010	4	16	11
Sep 2010	2	13	6
Oct 2010	11	16	3
Nov 2010	11	20	11
Dec 2010	9	15	8
Total 2010	77	228	101
Jan 2011	7	11	11
Feb 2011	4	10	6
Mar 2011	5	11	10
Apr 2011	8	14	12
May 2011	12	11	10
Jun 2011	6	11	11
Jul 2011	5	8	9
Aug 2011	7	5	19
Sep 2011	18	7	5
Oct 2011	2	14	12
Nov 2011	5	19	15
Dec 2011	2	7	12
Total 2011	81	128	132
Jan 2012	4	14	10
Feb 2012	7	17	15
Mar 2012	6	16	11
Apr 2012	10	10	8
May 2012	8	22	8
Jun 2012	8	13	10
Jul 2012	13	18	13
Aug 2012	4	13	14
Sep 2012	5	4	9
Oct 2012	4	11	17
Nov 2012	25	16	10
Dec 2012	22	18	9
Total 2012	116	172	134
Jan 2013	11	11	14
Feb 2013	11	6	5
Mar 2013	11	8	12
Apr 2013	11	15	16
May 2013	9	13	10
Jun 2013	6	13	19
Jul 2013	12	10	13
Aug 2013	6	5	3
Sep 2013	2	5	7
Oct 2013	5	8	10
Nov 2013	11	6	7
Dec 2013	7	5	5
Total 2013	102	105	121
Jan 2014	7	8	4
Feb 2014	3	7	5
Mar 2014	6	10	10
Apr 2014	4	5	7
May 2014	11	9	7
Jun 2014	7	6	7
Jul 2014	8	5	2
Aug 2014	10	7	6
Sep 2014	8	5	3
Oct 2014	4	8	4
Nov 2014	4	10	7
Dec 2014	15	8	5
Total 2014	87	88	67
Jan 2015	5	7	12
Feb 2015	9	8	9
Mar 2015	15	6	5
Apr 2015	5	14	7
May 2015	5	9	2
Jun 2015	4	10	4
Jul 2015	5	13	4
Aug 2015	7	4	5
Sep 2015	10	7	5
Oct 2015	6	17	5
Nov 2015	4	9	2
Dec 2015	11	10	7
Total 2015	86	114	67
Jan 2016	13	17	9
Feb 2016	13	8	9
Mar 2016	9	11	13
Apr 2016	5	11	3
May 2016	3	8	3
Jun 2016	5	7	5
Jul 2016	5	11	7
Aug 2016	4	5	4
Sep 2016	3	13	9
Oct 2016	4	10	6
Nov 2016	3	11	6
Dec 2016	0	5	5
Total 2016	67	117	79
Jan 2017	7	20	9
Feb 2017	1	17	3
Mar 2017	0	26	14
Apr 2017	2	20	55
May 2017	2	38	14
Jun 2017	4	19	5
Jul 2017	0	17	5
Aug 2017	0	18	5
Sep 2017	1	12	5
Oct 2017	5	13	6
Nov 2017	1	31	5
Dec 2017	0	23	8
Total 2017	23	254	134
Jan 2018	2	20	6
Feb 2018	3	14	3
Mar 2018	0	17	3
Apr 2018	0	13	5
May 2018	0	17	5
Jun 2018	0	12	3
Jul 2018	4	23	7
Aug 2018	0	13	2
Sep 2018	3	32	7
Oct 2018	0	57	5
Nov 2018	0	63	10
Dec 2018	1	24	2
Total 2018	13	305	58
Jan 2019	2	36	4
Feb 2019	0	24	5
Mar 2019	1	21	5
Apr 2019	1	28	9
May 2019	1	17	8
Jun 2019	1	20	8
Jul 2019	2	19	11
Aug 2019	1	9	9
Sep 2019	2	34	14
Oct 2019	3	70	10
Nov 2019	2	17	6
Dec 2019	0	16	11
Total 2019	16	311	100
Jan 2020	0	12	3
Feb 2020	1	16	8
Mar 2020	1	11	6
Apr 2020	0	9	7
May 2020	2	9	5
Jun 2020	3	8	8
Jul 2020	1	7	3
Aug 2020	1	6	2
Sep 2020	3	19	11
Oct 2020	2	16	5
Nov 2020	3	19	7
Dec 2020	4	17	3
Total 2020	21	149	68
Jan 2021	2	29	3
Feb 2021	4	24	5
Mar 2021	1	31	24
Apr 2021	0	14	9
Total 2021	7	98	41
Total	1835	4316	2553