αCaMKII-null (−/−)1,2 | Elimination of αCaMKII protein | Expression level of βCaMKII is unaltered1,2 but targeting of βCaMKII to PSD is increased2 | HC-LTP reduced1-3 | Hippocampus-dependent learning severely impaired but learning in some animals is observed after extended training1,2,6 |
| | | NC-LTP reduced in adult animals4-6 | |
| | | NC-LTP normal in young animals4,5 | |
| | | Decreased PPF1 | Increased seizure susceptibility7 (background dependent?2) |
| | | Normal I/O2 | |
αCaMKII-null (+/−)1,2 | Reduction of αCaMKII protein | αCaMKII 50% reduced, βCaMKII levels normal | HC-LTP normal2,8,9 | Normal learning2 or reduced hippocampus-dependent learning8 (background and protocol dependent) |
| | | NC-LTP reduced9 | |
| | | Decreased PPF8 | |
| | | Increased augmentation8 | Severely impaired remote memory10 |
| | | | Decreased fear and increased aggressive behavior11 |
αCaMKII-Floxed + CA3-cre12 | Elimination of αCaMKII protein in CA3 area | αCaMKII is absent from CA3 area after 4 months of age | Increased frequency facilitation | Not tested |
| | | Normal PPF and basal Pr | |
αCaMKII-T286A13 | Blocks T286 phosphorylation (no autonomous activity) | Normal expression level of α/βCaMKII; Ca2+ -independent activity reduced by 60% | HC-LTP and NC-LTP impaired13-16 | Severely impaired learning in water maze13,17 |
| | | Normal I/O13 | |
| | | | Unstable place cells18 |
Tg-αCaMKII-T286D19 | Mimics constitutive T286 phosphorylation | Ca2+ independent activity two-fold increased | Favors LTD19 | Impaired learning in Barnes maze21 |
| | | Normal NC-LTP20 | Impaired olfactory-based spatial learning22 |
| | | Normal PPF19 | Normal cued and contextual conditioning21 |
| | | | Unstable place cells23 |
Tg-αCaMKII-T286D24 (Tet inducible) | Mimics constitutive T286 phosphorylation in an inducible manner | Ca2+ -independent activity sixfold increased at maximum induction | Favors LTP at low expression level25 | Impaired learning in Barnes maze24 |
| | | Favors LTD at high expression level24,25 | Impaired learning in water maze25 |
| | | NC-LTP and LTD normal20 | Impaired cued and contextual conditioning24,25 |
αCaMKII-TT305/6VA2 | Blocks T305/T306 (inhibitory) phosphorylation | Increased levels of CaMKII in PSD | Favors LTP | Impaired water maze learning (initial learning okay) |
| | | Normal LTD and I/O | |
| | | | Impaired reversal learning |
| | | | Impaired context discrimination |
| | | | Old mice get seizures |
αCaMKII-T305D2 | Mimics constitutive T305 (inhibitory) phosphorylation | Severely reduced levels of α/βCaMKII in PSD | Favors LTD | Severely impaired in water maze and cued conditioning (cannot learn after over-training) |
| | | No LTP | |
| | | Normal LTD and I/O | |
αCaMKII-Δ3′UTR26 | Impairs dendritic targeting of mRNA | Reduced amount of PSD associated CaMKII | Normal (early) LTP | Impaired learning in water maze |
| | | Reduced late-phase LTP | Normal STM but impaired LTM after cued and contextual conditioning |
Tg-αCaMKII-F89G27 | Inducible system allowing rapid (8 min) reversible decrease of αCaMKII transgene activity | Ca2+ -(in)dependent activity twofold to threefold increased without inhibitor | Normal I/O and PPF | Impaired memory consolidation of contextual and cued conditioning when CaMKII activity is changed at the first week after training. |
| | | Enhanced LTD at 3 Hz | |
| | | Enhanced LTP at > 10Hz | |
Ube3A28,29 | Encodes E6-AP ubiquitin ligase; mouse model for Angelman's syndrome | Increased T286-P and T305-P30 | Impaired LTP28 | Impaired spatial learning28,29 |
| | Decreased αCaMKII in PSD30 | Normal I/O28 | Impaired motor coordination28,29 |
|
| Decreased PP1/PP2A activity30 |
| Inducible seizures28,29 |