Intrastriatal Transforming Growth Factor α Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons

Oliver Cooper; Ole Isacson

doi:10.1523/JNEUROSCI.2344-04.2004

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.2344-04.2004

PubMed

15483111

Published By

Society for Neuroscience

History

Received June 15, 2004
Revision received August 25, 2004
Accepted August 27, 2004
First published October 13, 2004.

Version of record published October 13, 2004.

Author Information

Oliver Cooper1 and
Ole Isacson1,2

¹Harvard University and McLean Hospital, National Institute of Neurological Disorders and Stroke Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts 02478, and ²Department of Neurology and Program of Neuroscience, Harvard Center for Neurodegeneration and Repair, Harvard Medical School, Boston, Massachusetts 02115

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Author contributions

Disclosures

Received June 15, 2004.
Revision received August 25, 2004.
Accepted August 27, 2004.

This work was supported by the Harvard Center for Neurodegeneration and Repair.
Correspondence should be addressed to Dr. Ole Isacson, McLean Hospital-Harvard Medical School, Neuroregeneration Laboratories, Mailman Research Center, 115 Mill Street, Belmont, MA 02478. E-mail: isacson{at}hms.harvard.edu.
Copyright © 2004 Society for Neuroscience 0270-6474/04/248924-08$15.00/0

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	Abstract	Full	Pdf
Oct 2004	644	308	594
Nov 2004	142	184	168
Dec 2004	79	105	64
Total 2004	865	597	826
Jan 2005	88	181	120
Feb 2005	66	137	90
Mar 2005	85	113	57
Apr 2005	31	115	49
May 2005	10	86	61
Jun 2005	23	106	61
Jul 2005	27	86	49
Aug 2005	14	64	31
Sep 2005	13	69	33
Oct 2005	22	77	51
Nov 2005	18	89	79
Dec 2005	21	67	34
Total 2005	418	1190	715
Jan 2006	15	53	30
Feb 2006	11	59	46
Mar 2006	11	52	31
Apr 2006	15	68	36
May 2006	18	50	39
Jun 2006	3	35	26
Jul 2006	7	61	62
Aug 2006	6	41	25
Sep 2006	14	54	33
Oct 2006	13	51	35
Nov 2006	11	50	26
Dec 2006	7	37	19
Total 2006	131	611	408
Jan 2007	15	27	20
Feb 2007	9	30	27
Mar 2007	7	38	25
Apr 2007	15	41	13
May 2007	7	36	21
Jun 2007	9	30	17
Jul 2007	11	20	12
Aug 2007	11	20	10
Sep 2007	6	25	21
Oct 2007	16	26	17
Nov 2007	13	44	21
Dec 2007	11	24	18
Total 2007	130	361	222
Jan 2008	11	27	37
Feb 2008	14	27	20
Mar 2008	19	28	32
Apr 2008	22	27	25
May 2008	30	19	19
Jun 2008	12	24	18
Jul 2008	46	23	17
Aug 2008	19	19	17
Sep 2008	44	16	14
Oct 2008	36	28	32
Nov 2008	31	16	20
Dec 2008	11	17	15
Total 2008	295	271	266
Jan 2009	7	18	11
Feb 2009	9	20	28
Mar 2009	29	10	16
Apr 2009	18	18	16
May 2009	13	19	14
Jun 2009	8	13	13
Jul 2009	16	19	16
Aug 2009	12	16	10
Sep 2009	14	22	17
Oct 2009	18	13	10
Nov 2009	19	22	24
Dec 2009	36	11	16
Total 2009	199	201	191
Jan 2010	15	11	6
Feb 2010	12	13	11
Mar 2010	35	10	14
Apr 2010	19	23	23
May 2010	6	16	17
Jun 2010	7	17	11
Jul 2010	5	12	19
Aug 2010	4	13	14
Sep 2010	7	5	10
Oct 2010	18	41	16
Nov 2010	18	24	15
Dec 2010	17	15	11
Total 2010	163	200	167
Jan 2011	8	15	15
Feb 2011	15	10	12
Mar 2011	15	18	15
Apr 2011	21	20	15
May 2011	11	16	11
Jun 2011	16	12	16
Jul 2011	10	5	5
Aug 2011	18	11	12
Sep 2011	13	10	14
Oct 2011	16	23	15
Nov 2011	16	23	16
Dec 2011	12	28	18
Total 2011	171	191	164
Jan 2012	21	18	13
Feb 2012	26	18	17
Mar 2012	36	17	19
Apr 2012	16	16	10
May 2012	19	16	13
Jun 2012	18	9	10
Jul 2012	10	9	10
Aug 2012	5	6	5
Sep 2012	8	6	10
Oct 2012	12	12	14
Nov 2012	29	13	13
Dec 2012	34	7	8
Total 2012	234	147	142
Jan 2013	24	11	8
Feb 2013	20	7	5
Mar 2013	23	12	10
Apr 2013	12	8	7
May 2013	16	6	5
Jun 2013	16	13	11
Jul 2013	10	6	6
Aug 2013	7	6	3
Sep 2013	7	5	4
Oct 2013	16	3	4
Nov 2013	13	5	5
Dec 2013	13	5	3
Total 2013	177	87	71
Jan 2014	24	3	6
Feb 2014	12	7	7
Mar 2014	24	23	18
Apr 2014	21	5	2
May 2014	17	5	7
Jun 2014	15	12	3
Jul 2014	35	9	4
Aug 2014	7	8	7
Sep 2014	7	7	7
Oct 2014	16	10	10
Nov 2014	22	21	10
Dec 2014	20	3	5
Total 2014	220	113	86
Jan 2015	10	11	7
Feb 2015	11	5	7
Mar 2015	20	7	9
Apr 2015	13	4	5
May 2015	12	5	5
Jun 2015	5	6	7
Jul 2015	6	3	5
Aug 2015	1	2	2
Sep 2015	7	17	6
Oct 2015	6	72	6
Nov 2015	7	97	5
Dec 2015	12	70	6
Total 2015	110	299	70
Jan 2016	14	26	9
Feb 2016	14	49	16
Mar 2016	8	41	3
Apr 2016	19	35	1
May 2016	7	32	6
Jun 2016	3	51	1
Jul 2016	16	56	8
Aug 2016	14	11	7
Sep 2016	15	51	7
Oct 2016	9	32	9
Nov 2016	17	12	6
Dec 2016	4	9	1
Total 2016	140	405	74
Jan 2017	1	9	3
Feb 2017	1	22	3
Mar 2017	0	18	5
Apr 2017	0	19	8
May 2017	2	29	3
Jun 2017	3	9	2
Jul 2017	0	13	1
Aug 2017	0	11	6
Sep 2017	0	8	1
Oct 2017	1	9	3
Nov 2017	0	12	1
Dec 2017	0	11	1
Total 2017	8	170	37
Jan 2018	0	14	1
Feb 2018	1	7	5
Mar 2018	0	12	3
Apr 2018	1	287	3
May 2018	1	310	1
Jun 2018	0	24	4
Jul 2018	5	8	6
Aug 2018	1	13	6
Sep 2018	2	14	2
Oct 2018	3	11	3
Nov 2018	1	11	6
Dec 2018	1	4	2
Total 2018	16	715	42
Jan 2019	4	7	4
Feb 2019	3	15	10
Mar 2019	3	16	4
Apr 2019	1	8	5
May 2019	3	7	8
Jun 2019	3	6	2
Jul 2019	2	3	3
Aug 2019	4	8	5
Sep 2019	3	4	7
Oct 2019	7	9	3
Nov 2019	0	7	11
Dec 2019	1	11	6
Total 2019	34	101	68
Jan 2020	2	8	2
Feb 2020	2	128	2
Mar 2020	0	7	4
Apr 2020	0	4	5
May 2020	0	9	3
Jun 2020	1	6	9
Jul 2020	0	10	6
Aug 2020	0	9	3
Sep 2020	1	26	15
Oct 2020	2	13	6
Nov 2020	4	12	13
Dec 2020	2	15	7
Total 2020	14	247	75
Jan 2021	2	18	5
Feb 2021	2	19	7
Mar 2021	1	2	3
Total 2021	5	39	15
Total	3330	5945	3639