Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine3 Receptor Revealed by Unnatural Amino Acid Mutagenesis

Darren L. Beene; Kerry L. Price; Henry A. Lester; Dennis A. Dougherty; Sarah C. R. Lummis

doi:10.1523/JNEUROSCI.2429-04.2004

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.2429-04.2004

PubMed

15483128

Published By

Society for Neuroscience

History

Received April 23, 2004
Accepted July 20, 2004
First published October 13, 2004.

Version of record published October 13, 2004.

Author Information

Darren L. Beene1,*,
Kerry L. Price3,*,
Henry A. Lester2,
Dennis A. Dougherty1, and
Sarah C. R. Lummis3

Divisions of ¹Chemistry and Chemical Engineering and ²Biology, California Institute of Technology, Pasadena, California 91125, and ³Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom

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Author contributions

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Disclosures

Received April 23, 2004.
Accepted July 20, 2004.

This work was supported by The Wellcome Trust (S.C.R.L. is a Wellcome Trust Senior Research Fellow in Basic Biomedical Science), the Medical Research Council (a studentship to K.L.P.), and the National Institutes of Health (Grants NS11756 and NS34407). We thank Dr. Nigel Unwin for helpful discussions.
Correspondence should be addressed to Sarah C. R. Lummis, Department of Biochemistry, Tennis Court Road, Cambridge CB2 1QW, UK. E-mail: sl120{at}cam.ac.uk.
Copyright © 2004 Society for Neuroscience 0270-6474/04/249097-08$15.00/0
↵* D.L.B. and K.L.P. contributed equally to this work.

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	Abstract	Full	Pdf
Oct 2004	241	107	216
Nov 2004	45	104	76
Dec 2004	22	33	30
Total 2004	308	244	322
Jan 2005	13	57	57
Feb 2005	26	55	30
Mar 2005	30	39	19
Apr 2005	2	38	19
May 2005	16	54	35
Jun 2005	12	32	10
Jul 2005	7	35	17
Aug 2005	8	30	14
Sep 2005	5	31	9
Oct 2005	5	26	23
Nov 2005	6	39	29
Dec 2005	8	24	18
Total 2005	138	460	280
Jan 2006	4	24	8
Feb 2006	1	41	23
Mar 2006	1	28	16
Apr 2006	7	34	22
May 2006	4	20	19
Jun 2006	1	17	11
Jul 2006	4	15	14
Aug 2006	2	12	7
Sep 2006	2	11	11
Oct 2006	0	21	11
Nov 2006	4	21	18
Dec 2006	2	15	9
Total 2006	32	259	169
Jan 2007	1	18	14
Feb 2007	3	16	13
Mar 2007	5	13	17
Apr 2007	7	16	13
May 2007	2	13	4
Jun 2007	4	9	7
Jul 2007	6	26	15
Aug 2007	1	4	0
Sep 2007	5	10	13
Oct 2007	9	13	13
Nov 2007	7	13	7
Dec 2007	9	12	10
Total 2007	59	163	126
Jan 2008	6	7	8
Feb 2008	7	11	8
Mar 2008	9	14	12
Apr 2008	10	11	9
May 2008	6	9	11
Jun 2008	13	9	6
Jul 2008	4	11	14
Aug 2008	4	11	4
Sep 2008	9	13	5
Oct 2008	20	17	7
Nov 2008	14	9	9
Dec 2008	9	12	5
Total 2008	111	134	98
Jan 2009	2	9	6
Feb 2009	10	15	13
Mar 2009	18	10	12
Apr 2009	12	7	9
May 2009	2	8	6
Jun 2009	3	9	5
Jul 2009	5	11	6
Aug 2009	8	4	4
Sep 2009	2	8	5
Oct 2009	4	3	5
Nov 2009	7	6	4
Dec 2009	13	11	10
Total 2009	86	101	85
Jan 2010	14	5	5
Feb 2010	1	5	5
Mar 2010	8	14	9
Apr 2010	1	4	4
May 2010	5	6	6
Jun 2010	5	6	4
Jul 2010	3	4	4
Aug 2010	4	5	4
Sep 2010	2	8	7
Oct 2010	4	9	6
Nov 2010	13	16	9
Dec 2010	6	11	7
Total 2010	66	93	70
Jan 2011	11	5	6
Feb 2011	6	7	8
Mar 2011	5	8	4
Apr 2011	10	9	5
May 2011	9	16	11
Jun 2011	7	14	7
Jul 2011	9	10	14
Aug 2011	11	2	14
Sep 2011	12	7	13
Oct 2011	15	10	7
Nov 2011	11	13	15
Dec 2011	10	11	17
Total 2011	116	112	121
Jan 2012	19	9	9
Feb 2012	7	10	8
Mar 2012	8	5	5
Apr 2012	7	12	10
May 2012	12	11	14
Jun 2012	10	2	10
Jul 2012	5	7	12
Aug 2012	9	9	7
Sep 2012	8	9	9
Oct 2012	18	4	10
Nov 2012	26	4	11
Dec 2012	21	4	3
Total 2012	150	86	108
Jan 2013	12	7	7
Feb 2013	16	9	6
Mar 2013	24	15	10
Apr 2013	8	20	12
May 2013	7	15	10
Jun 2013	3	3	2
Jul 2013	3	2	0
Aug 2013	7	4	5
Sep 2013	7	4	5
Oct 2013	7	3	14
Nov 2013	4	3	9
Dec 2013	3	5	7
Total 2013	101	90	87
Jan 2014	2	3	6
Feb 2014	6	5	11
Mar 2014	4	8	6
Apr 2014	4	5	11
May 2014	9	6	7
Jun 2014	9	2	8
Jul 2014	20	11	4
Aug 2014	5	2	5
Sep 2014	5	5	4
Oct 2014	7	3	4
Nov 2014	7	6	4
Dec 2014	6	3	7
Total 2014	84	59	77
Jan 2015	6	5	4
Feb 2015	4	3	6
Mar 2015	9	5	10
Apr 2015	9	13	12
May 2015	4	4	11
Jun 2015	6	3	5
Jul 2015	5	4	6
Aug 2015	2	4	3
Sep 2015	6	2	3
Oct 2015	6	6	8
Nov 2015	2	8	5
Dec 2015	16	3	12
Total 2015	75	60	85
Jan 2016	12	3	3
Feb 2016	9	9	11
Mar 2016	4	6	9
Apr 2016	8	12	3
May 2016	11	8	7
Jun 2016	3	8	4
Jul 2016	6	4	3
Aug 2016	6	2	3
Sep 2016	15	7	2
Oct 2016	5	9	9
Nov 2016	6	13	22
Dec 2016	1	6	2
Total 2016	86	87	78
Jan 2017	1	9	1
Feb 2017	0	11	4
Mar 2017	0	12	3
Apr 2017	1	9	8
May 2017	3	24	3
Jun 2017	1	9	2
Jul 2017	0	9	6
Aug 2017	0	12	5
Sep 2017	0	8	3
Oct 2017	0	7	6
Nov 2017	1	13	5
Dec 2017	2	15	3
Total 2017	9	138	49
Jan 2018	2	17	9
Feb 2018	0	4	7
Mar 2018	3	21	5
Apr 2018	0	10	4
May 2018	0	25	2
Jun 2018	1	13	3
Jul 2018	2	15	3
Aug 2018	2	11	1
Sep 2018	1	18	1
Oct 2018	1	32	6
Nov 2018	1	30	4
Dec 2018	0	15	2
Total 2018	13	211	47
Jan 2019	2	2	1
Feb 2019	4	16	7
Mar 2019	1	11	5
Apr 2019	2	11	1
May 2019	2	15	10
Jun 2019	0	12	3
Jul 2019	1	14	8
Aug 2019	0	15	9
Sep 2019	0	18	6
Oct 2019	3	20	4
Nov 2019	3	15	11
Dec 2019	3	27	7
Total 2019	21	176	72
Jan 2020	6	12	4
Feb 2020	1	6	2
Mar 2020	2	17	4
Apr 2020	3	19	6
May 2020	3	19	13
Jun 2020	1	9	6
Jul 2020	2	20	0
Aug 2020	2	28	3
Sep 2020	0	92	6
Oct 2020	0	30	6
Nov 2020	1	32	6
Dec 2020	3	37	3
Total 2020	24	321	59
Jan 2021	3	34	9
Feb 2021	0	39	6
Mar 2021	1	11	5
Total 2021	4	84	20
Total	1483	2878	1953