Article Figures & Data
Figures
- Figure 1.
Top, Photograph showing the extended forebrain on the right (neonatally operated) hemisphere. The forebrain extension filled the cavity vacated by the neonatal bulbectomy. Frontal levels A, B, and C are approximately those illustrated in photomicrographs A-C. A-C, Photomicrographs of sections through the anterior (A) and middle (B) portion of the forebrain extension and through the rostral anterior olfactory nucleus (C). As shown, the extended forebrain tissue is heavily invested with WGA-HRP reaction product, and numerous glomerular-like clusters can be identified within the anterior olfactory nucleus. D, Higher-magnification photomicrograph of region outlined in C showing details of glomerular-like clusters of axons within the anterior olfactory nucleus.
- Figure 2.
A, Photomicrograph of a section through the frontal cortex and posterior aspect of the anterior olfactory nucleus in another experimental rat. The dense WGA-HRP reaction product in the AON is representative of that found in most NBXi rats that could detect and discriminate odors. B, Photomicrograph (using polarized light optics) showing a stream of fibers directed toward ependyma juxtaposed to the anterior limb of the anterior commissure and fibers entering this zone (C).
- Figure 3.
Mean performance of nosmic NBXi rats, control rats, and rats with olfactory bulb remnants on odor detection tasks (top left graph) and odor discrimination tasks (top right graph). In odor detection tasks A, B, C, D, and E, the S+ stimulus was jasmine perfume, citral, 10% and 1% acetic acid, and (+)-carvone, respectively (see Materials and Methods). Each data point is the mean score on a block of 20 trials. The bottom graphs show performance of the two NBXi rats that performed best (rats AA1 and EE1) and one rat (AA5) representative of those that performed more poorly on the odor detection and discrimination tasks.
Tables
- Table 1.
Total errors in a 200 trial session or errors to criterion of 85% correct responding for each of the experimental rats that could detect odors and mean scores for controls on each odor detection and discrimination task
Rat number EA 5%a EA 1% EA 0.1% EA 0.01% A B C D E D1 D2 D3 D4 AA1 14 0 3 2 3 2 1 9 7 7 7 17 27 AA2 14 2 3 7 6 8 1 1 46 10 15 76** 46 AA5 117 71 97** 100** 93** 90** 45 8 64 69 93** 72** 64 AA6 9 8 99** 101** 94** 93** 56 95** 79 96** 98** 82** 72 EE1 17 1 5 5 5 40 2 3 26 3 2 91** 56 EE2 18 7 14 28 6 79** 10 18 15 97** 10 107** 25 EE4 56 10 19 105** 93** 103** 91** 53 7 29 92** 33 43 EE5 16 6 22 6 3 7 7 43 86** 9 20 25 86** A16 111 3 12 15 75 * 27 * * 89** * 107** * A27 2 16 10 9 17 * 22 * * 14 * 59 * D5 139 7 32 19 14 * 97** * 88** 103** * 94** 98** D9 6 3 1 10 5 * 15 * 56 12 * 33 93** D15 154 5 42 43 8 * 34 * 34 92** * 94** 39 D24 3 1 0 63** 1 * 14 * 42 12 * 11 31 D27 201 3 22 98** 19 * 33 * 23 21 * * 100** E6 4 2 91** 98** 1 * 12 12 2 * 13 16 E7 19 0 1 2 12 * 43 * 17 23 * 93** 17 Percentageb 100 100 82 65 82 50 88 88 87 70 62 44 73 Controlsc 4.2 6.1 13.5 8.6 3.4 5.3 2.7 3.7 5.1 2.6 6.2 9.3 31.7 -
↵ a A maximum of 600 trials was allowed on the 5% ethyl acetate detection, 200 trails on all other tasks. EA, Ethyl acetate.
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↵ b Percentage of rats tested that reached criterion performance.
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↵ c Mean errors. All control rats reached criterion on all tasks. A-E, Perfume, citral, 10% acetic acid, 1% acetic acid, and (+)-carvone detection tasks, respectively. D1-D4, Perfume discrimination, acetic acid versus caproic acid, acetic acid versus propionic acid, and (+)-carvone versus (−)-carvone discrimination tasks, respectively.
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↵* Was not tested.
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↵** Did not reach criterion of 85% correct responding.
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