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Behavioral/Systems/Cognitive

Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory

Lisa Marshall, Matthias Mölle, Manfred Hallschmid and Jan Born
Journal of Neuroscience 3 November 2004, 24 (44) 9985-9992; DOI: https://doi.org/10.1523/JNEUROSCI.2725-04.2004
Lisa Marshall
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Matthias Mölle
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Manfred Hallschmid
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Jan Born
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This article has a correction. Please see:

  • Correction - January 12, 2005

Abstract

In humans, weak transcranial direct current stimulation (tDCS) modulates excitability in the motor, visual, and prefrontal cortex. Periods rich in slow-wave sleep (SWS) not only facilitate the consolidation of declarative memories, but in humans, SWS is also accompanied by a pronounced endogenous transcortical DC potential shift of negative polarity over frontocortical areas. To experimentally induce widespread extracellular negative DC potentials, we applied anodal tDCS (0.26 mA/cm2) repeatedly (over 30 min) bilaterally at frontocortical electrode sites during a retention period rich in SWS. Retention of declarative memories (word pairs) and also nondeclarative memories (mirror tracing skills) learned previously was tested after this period and compared with retention performance after placebo stimulation as well as after retention intervals of wakefulness. Compared with placebo stimulation, anodal tDCS during SWS-rich sleep distinctly increased the retention of word pairs (p < 0.005). When applied during the wake retention interval, tDCS did not affect declarative memory. Procedural memory was also not affected by tDCS. Mood was improved both after tDCS during sleep and during wake intervals. tDCS increased sleep depth toward the end of the stimulation period, whereas the average power in the faster frequency bands (θ,α, andβ) was reduced. Acutely, anodal tDCS increased slow oscillatory activity <3 Hz. We conclude that effects of tDCS involve enhanced generation of slow oscillatory EEG activity considered to facilitate processes of neuronal plasticity. Shifts in extracellular ionic concentration in frontocortical tissue (expressed as negative DC potentials during SWS) may facilitate sleep-dependent consolidation of declarative memories.

  • declarative memory
  • direct current (DC) potential
  • electroencephalography (EEG)
  • nonrapid eye movement (NonREM) sleep
  • slow oscillation
  • transcranial direct current stimulation (tDCS)
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The Journal of Neuroscience: 24 (44)
Journal of Neuroscience
Vol. 24, Issue 44
3 Nov 2004
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Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory
Lisa Marshall, Matthias Mölle, Manfred Hallschmid, Jan Born
Journal of Neuroscience 3 November 2004, 24 (44) 9985-9992; DOI: 10.1523/JNEUROSCI.2725-04.2004

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Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory
Lisa Marshall, Matthias Mölle, Manfred Hallschmid, Jan Born
Journal of Neuroscience 3 November 2004, 24 (44) 9985-9992; DOI: 10.1523/JNEUROSCI.2725-04.2004
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