Article Figures & Data
Figures
- Figure 3.
Statistical gray matter maps of the entire brain showing volume reductions of met-BDNF carriers in comparison to val/val-BDNF have been transformed from MNI space in Talairach space and converted to z-scores. Maximal z-scores within cortical regions have been projected onto a brain surface. The figure shows that the met-BDNF group has significantly reduced cortical volume (red and yellow areas) compared with val/val-BDNF carriers being found predominantly at the lateral convexity of the frontal lobe. Peak differences (red) are also found within dorsolateral prefrontal cortical areas, which are related to memory function.
- Figure 2.
Mean differences (±SEM) in hippocampal volume reduction in met-BDNF carriers relative to val/val-BDNF subjects within regions of statistical significance (p = 0.05) as shown in Figure 1. Measures for hippocampal volume have been extracted from the hippocampal cluster and transformed in percentage volume relative to val/val-BDNF while controlling for confounding variables such as age, gender, and total gray matter volume.
- Figure 1.
Statistical maps of t-transformed hippocampal volume differences derived by optimized voxel-based morphometry in met relative to val/val-BDNF carriers thresholded at p = 0.05 (corrected) in coronal, sagittal, and axial views, showing bilateral significant hippocampal volume reduction in met-BDNF carriers.
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