Article Figures & Data
Figures
- Figure 3.
DLPFC gray matter density as a function of subtypes of CBP. A, DLPFC gray matter density is highest in controls and lowest in neuropathic patients. Gray matter density is in arbitrary units derived from regional eigenvariates. B, Somatotopy of pain is shown on the figurines to the right, for subtypes of CBP. Color code is the number of subjects localizing their pain to indicated body site. Only the 17 CBP patients used in VBM are shown. The remaining CBP patients had a similar somatotopy for CBP.
- Figure 1.
Decreased whole-brain cortical gray matter volume in CBP subjects. Skull-normalized neocortical gray matter volumes are shown for CBP subjects and matched control subjects. A, Gray matter volumes as a function of age. The difference in intercepts corresponds to an average decrease of 30 cm3 in gray matter volume in CBP compared with the normal subjects. B, Gray matter volumes as a function of pain duration, after correcting for age and gender. Individual control subjects are shown at pain duration = 0. nuCBP and non-nuCBP CBP patient data are presented separately. The horizontal line is the mean volume for controls. Individual whole-brain gray matter volumes in CBP subjects are all below the mean volume for controls. Group-averaged gray matter volumes (mean ± SEM) are shown in the right bar graph, before (top) and after (bottom) correcting for age and gender. Lines are best linear fits for each group.
- Figure 2.
Regional gray matter density decreases in CBP subjects. A nonparametric comparison of voxel-based morphometry between CBP and control subjects is shown. A, Gray matter density is bilaterally reduced in the DLPFC. The result is from a VBM permutation-based pseudo-t test and voxel-level contrasts when all brain gray matter voxels were compared between controls and CBP subjects. Pseudocolor highly positive values indicate regions where gray matter density was reduced in CBP subjects (controls - CBP). B, A nonparametric comparison spatially limited to the thalami revealed a significant decrease in gray matter density in the right anterior thalamus. A slice at the peak of decreased thalamic gray matter is shown. Pseudo-t values are color coded; range is 3-6.
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