A Single Infusion of Brain-Derived Neurotrophic Factor into the Ventral Tegmental Area Induces Long-Lasting Potentiation of Cocaine Seeking after Withdrawal

Lin Lu; Jack Dempsey; Shirley Y. Liu; Jennifer M. Bossert; Yavin Shaham

doi:10.1523/JNEUROSCI.5124-03.2004

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.5124-03.2004

PubMed

14973246

Published By

Society for Neuroscience

History

Received October 28, 2003
Revision received December 18, 2003
Accepted December 22, 2003
First published February 18, 2004.

Version of record published February 18, 2004.

Author Information

Lin Lu,
Jack Dempsey,
Shirley Y. Liu,
Jennifer M. Bossert, and
Yavin Shaham

Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224

View Full Text

Author contributions

Disclosures

Received October 28, 2003.
Revision received December 18, 2003.
Accepted December 22, 2003.

This work was supported by the National Institute on Drug Abuse, Intramural Research Program. We thank Drs. Barry Hoffer, Yun Wang, Dorit Ron, Bruce Hope, and Jane Stewart for helpful suggestions and comments. We also thank Polly Robarts and Kelly Badger for technical assistance.
Correspondence should be addressed to Dr. Yavin Shaham, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224. E-mail: yshaham{at}intra.nida.nih.gov.
Copyright © 2004 Society for Neuroscience 0270-6474/04/241604-08$15.00/0

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	Abstract	Full	Pdf
Feb 2004	448	126	447
Mar 2004	87	158	182
Apr 2004	31	108	94
May 2004	37	87	50
Jun 2004	25	67	48
Jul 2004	18	59	25
Aug 2004	28	77	47
Sep 2004	32	59	49
Oct 2004	18	50	36
Nov 2004	27	55	38
Dec 2004	24	62	27
Total 2004	775	908	1043
Jan 2005	48	40	42
Feb 2005	22	45	36
Mar 2005	27	54	41
Apr 2005	8	39	47
May 2005	13	54	60
Jun 2005	12	40	37
Jul 2005	7	34	28
Aug 2005	7	25	35
Sep 2005	11	37	31
Oct 2005	8	35	30
Nov 2005	19	71	41
Dec 2005	17	34	29
Total 2005	199	508	457
Jan 2006	6	41	26
Feb 2006	8	36	20
Mar 2006	10	41	28
Apr 2006	11	32	25
May 2006	4	29	29
Jun 2006	7	23	21
Jul 2006	4	19	14
Aug 2006	3	28	20
Sep 2006	4	13	13
Oct 2006	4	25	20
Nov 2006	16	26	22
Dec 2006	2	17	8
Total 2006	79	330	246
Jan 2007	8	34	32
Feb 2007	11	18	12
Mar 2007	5	25	21
Apr 2007	4	24	21
May 2007	8	17	12
Jun 2007	6	14	11
Jul 2007	7	24	17
Aug 2007	7	20	25
Sep 2007	8	16	18
Oct 2007	5	34	28
Nov 2007	11	23	20
Dec 2007	6	15	11
Total 2007	86	264	228
Jan 2008	4	19	17
Feb 2008	8	22	23
Mar 2008	15	22	16
Apr 2008	18	27	23
May 2008	6	18	19
Jun 2008	17	13	15
Jul 2008	6	23	20
Aug 2008	8	27	15
Sep 2008	9	21	18
Oct 2008	22	23	24
Nov 2008	32	17	21
Dec 2008	7	16	16
Total 2008	152	248	227
Jan 2009	5	17	13
Feb 2009	10	13	12
Mar 2009	14	22	24
Apr 2009	7	20	19
May 2009	10	20	18
Jun 2009	13	17	22
Jul 2009	16	17	30
Aug 2009	5	23	19
Sep 2009	14	7	10
Oct 2009	11	17	14
Nov 2009	23	20	22
Dec 2009	17	16	13
Total 2009	145	209	216
Jan 2010	12	14	11
Feb 2010	10	14	14
Mar 2010	10	15	20
Apr 2010	5	17	8
May 2010	7	24	17
Jun 2010	10	26	14
Jul 2010	6	14	18
Aug 2010	6	15	12
Sep 2010	13	19	18
Oct 2010	19	32	29
Nov 2010	10	17	21
Dec 2010	11	16	17
Total 2010	119	223	199
Jan 2011	18	23	20
Feb 2011	9	13	13
Mar 2011	19	23	19
Apr 2011	31	9	10
May 2011	14	22	19
Jun 2011	7	13	11
Jul 2011	11	19	11
Aug 2011	21	12	26
Sep 2011	18	20	17
Oct 2011	11	17	18
Nov 2011	16	15	14
Dec 2011	22	20	25
Total 2011	197	206	203
Jan 2012	27	12	16
Feb 2012	22	9	10
Mar 2012	25	15	14
Apr 2012	33	18	20
May 2012	25	17	19
Jun 2012	23	5	12
Jul 2012	17	15	23
Aug 2012	10	17	17
Sep 2012	12	6	5
Oct 2012	15	12	22
Nov 2012	38	16	26
Dec 2012	32	13	17
Total 2012	279	155	201
Jan 2013	18	10	17
Feb 2013	20	5	13
Mar 2013	37	22	27
Apr 2013	28	15	29
May 2013	20	12	18
Jun 2013	21	10	9
Jul 2013	7	16	15
Aug 2013	9	13	15
Sep 2013	20	15	12
Oct 2013	10	17	18
Nov 2013	11	6	9
Dec 2013	9	14	20
Total 2013	210	155	202
Jan 2014	22	10	13
Feb 2014	9	20	21
Mar 2014	21	23	20
Apr 2014	10	22	15
May 2014	12	32	21
Jun 2014	19	18	15
Jul 2014	21	20	15
Aug 2014	15	26	18
Sep 2014	9	11	7
Oct 2014	23	39	13
Nov 2014	18	18	10
Dec 2014	15	49	19
Total 2014	194	288	187
Jan 2015	19	25	8
Feb 2015	11	9	7
Mar 2015	33	17	16
Apr 2015	13	14	14
May 2015	18	7	11
Jun 2015	26	10	8
Jul 2015	14	12	6
Aug 2015	18	8	3
Sep 2015	11	13	5
Oct 2015	15	20	17
Nov 2015	26	14	9
Dec 2015	25	17	14
Total 2015	229	166	118
Jan 2016	14	3	5
Feb 2016	19	11	9
Mar 2016	19	24	8
Apr 2016	13	6	7
May 2016	27	15	8
Jun 2016	14	6	11
Jul 2016	24	1	13
Aug 2016	7	7	6
Sep 2016	12	7	6
Oct 2016	5	12	8
Nov 2016	5	17	17
Dec 2016	3	19	18
Total 2016	162	128	116
Jan 2017	3	14	5
Feb 2017	4	12	11
Mar 2017	2	21	7
Apr 2017	2	16	4
May 2017	5	51	5
Jun 2017	1	19	7
Jul 2017	1	17	2
Aug 2017	4	17	2
Sep 2017	3	21	2
Oct 2017	6	26	6
Nov 2017	1	18	6
Dec 2017	0	27	6
Total 2017	32	259	63
Jan 2018	3	23	6
Feb 2018	1	11	3
Mar 2018	4	20	4
Apr 2018	3	36	11
May 2018	4	36	10
Jun 2018	0	17	3
Jul 2018	6	7	3
Aug 2018	2	24	1
Sep 2018	1	21	3
Oct 2018	1	28	5
Nov 2018	6	45	6
Dec 2018	6	13	7
Total 2018	37	281	62
Jan 2019	5	23	13
Feb 2019	3	23	11
Mar 2019	5	18	13
Apr 2019	1	18	8
May 2019	4	22	6
Jun 2019	1	13	5
Jul 2019	0	17	8
Aug 2019	1	17	6
Sep 2019	1	48	4
Oct 2019	4	98	4
Nov 2019	4	17	11
Dec 2019	2	13	4
Total 2019	31	327	93
Jan 2020	3	21	4
Feb 2020	1	109	4
Mar 2020	2	25	4
Apr 2020	0	7	1
May 2020	0	15	7
Jun 2020	6	5	6
Jul 2020	0	10	3
Aug 2020	3	4	3
Sep 2020	1	15	6
Oct 2020	3	22	13
Nov 2020	6	14	11
Dec 2020	7	23	2
Total 2020	32	270	64
Jan 2021	2	34	10
Feb 2021	3	24	9
Mar 2021	5	30	22
Apr 2021	1	8	6
Total 2021	11	96	47
Total	2969	5021	3972