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Cellular/Molecular

Different Behavior toward Bovine Spongiform Encephalopathy Infection of Bovine Prion Protein Transgenic Mice with One Extra Repeat Octapeptide Insert Mutation

J. Castilla, A. Gutiérrez-Adán, A. Brun, B. Pintado, B. Parra, M. A. Ramírez, F. J. Salguero, F. Díaz San Segundo, A. Rábano, M. J. Cano and J. M. Torres
Journal of Neuroscience 3 March 2004, 24 (9) 2156-2164; https://doi.org/10.1523/JNEUROSCI.3811-03.2004
J. Castilla
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A. Gutiérrez-Adán
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A. Brun
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B. Pintado
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B. Parra
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M. A. Ramírez
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F. J. Salguero
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F. Díaz San Segundo
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A. Rábano
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M. J. Cano
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J. M. Torres
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3811-03.2004
PubMed 
14999066
Published By 
Society for Neuroscience
History 
  • Received August 15, 2003
  • Revision received December 22, 2003
  • Accepted December 24, 2003
  • First published March 3, 2004.
  • Version of record published March 3, 2004.
Copyright & Usage 
Copyright © 2004 Society for Neuroscience 0270-6474/04/242156-09.00/0

Author Information

  1. J. Castilla1,
  2. A. Gutiérrez-Adán2,
  3. A. Brun1,
  4. B. Pintado2,
  5. B. Parra1,
  6. M. A. Ramírez2,
  7. F. J. Salguero1,
  8. F. Díaz San Segundo1,
  9. A. Rábano3,
  10. M. J. Cano1, and
  11. J. M. Torres1
  1. 1Center of Animal Health Investigation, National Institute of Agricultural Technology and Investigation, Valdeolmos, 28130 Madrid, Spain, 2Department of Animal Reproduction and Zoogenetic Resources Conservation, 28040 Madrid, Spain, and 3Neuropathology Laboratory, Alcorcón Hospital, Alcorcón, 28922 Madrid, Spain
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Author contributions

Disclosures

    • Received August 15, 2003.
    • Revision received December 22, 2003.
    • Accepted December 24, 2003.
  • This work was supported by a Spanish national grant (SC00-055). We thank J. C. Manson for supplying the Prnp -/- mice, D. R. Borchelt for supplying the MoPrP.Xho plasmid, and the Veterinary Laboratory Agency (Weybridge, UK) for supplying BSE brain material. We also acknowledge Fernando Rodríguez for critical reading of this manuscript.

  • Correspondence should be addressed to Dr. Juan María Torres Trillo, Centro de Investigación en Sanidad Animal, INIA, Valdeolmos, 28130 Madrid, Spain. E-mail: jmtorres{at}inia.es.

  • Copyright © 2004 Society for Neuroscience 0270-6474/04/242156-09$15.00/0

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The Journal of Neuroscience: 24 (9)
Journal of Neuroscience
Vol. 24, Issue 9
3 Mar 2004
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Different Behavior toward Bovine Spongiform Encephalopathy Infection of Bovine Prion Protein Transgenic Mice with One Extra Repeat Octapeptide Insert Mutation
J. Castilla, A. Gutiérrez-Adán, A. Brun, B. Pintado, B. Parra, M. A. Ramírez, F. J. Salguero, F. Díaz San Segundo, A. Rábano, M. J. Cano, J. M. Torres
Journal of Neuroscience 3 March 2004, 24 (9) 2156-2164; DOI: 10.1523/JNEUROSCI.3811-03.2004

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Different Behavior toward Bovine Spongiform Encephalopathy Infection of Bovine Prion Protein Transgenic Mice with One Extra Repeat Octapeptide Insert Mutation
J. Castilla, A. Gutiérrez-Adán, A. Brun, B. Pintado, B. Parra, M. A. Ramírez, F. J. Salguero, F. Díaz San Segundo, A. Rábano, M. J. Cano, J. M. Torres
Journal of Neuroscience 3 March 2004, 24 (9) 2156-2164; DOI: 10.1523/JNEUROSCI.3811-03.2004
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