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- supplemental material - Supplemental Figure S1. Plateau potentials in different pyramidal cell types Electrophysiological profiles of visually identified pyramidal neurons were determined (Column A) before single glutamate pulses (arrowhead) were delivered on basal dendrites using the �sniffing� method (Column B). The distance from the tip of the glutamate stimulation pipette to the center of the cell body, as well as the intensity of the glutamate iontophoretic current are displayed in boxes. All neurons in this figure were patched in Layer V except the oscillatory bursting neuron (panel d) which was found in Layer II/III. Arrow marks a characteristic depolarizing afterpotential (DAP).
- supplemental material - Supplemental Figure S2. Input-output function of basal dendrites (group data). Glutamate pulses, of gradually growing intensity, were delivered on visually identified basal dendrites (70-100 ?m away from the cell body, mean=80.5+7.6 ?m, n=15) and somatic plateau depolarizations were recorded in current clamp, as described in Fig. 2D. Absolute values of plateau amplitude (A), plateau duration (C), and number of action potentials per plateau (D), were plotted against the intensity of the glutamate iontophoretic current, for each neuron. In panel B, the mean plateau amplitude was calculated for each stimulation intensity, across 15 data sets obtained in 15 neurons.
- supplemental material - Supplemental Figure S3. Temporal relation between dendritic and somatic plateau depolarizations. Same data as in Fig. 5B, was temporally filtered (low-pass Gaussian, 25 Hz cut-off, high-pass Butterworth, 0.4 Hz) and superimposed with unfiltered whole-cell recording (5 kHz). Red trace - optical signal from the target dendrite (filtered). Blue trace - whole cell somatic recording (filtered). Black trace � whole cell somatic recording (unfiltered). Inset: A part of the figure is blown up to show that the front of dendritic depolarization precedes the somatic signal by 8.5 ms, measured at 50% plateau amplitude.