Article Figures & Data
Figures
- Figure 1.
The effect of exercise on Aβ load in three different brain regions of TgCRND8 mice. Exercising animals show a significant (*) reduction in Aβ immunoreactivity in the frontal cortex (p = 0.018) and cortex at the level of the hippocampus (p = 0.0003). There is also a decrease in Aβ in the hippocampus of exercising animals (p = 0.06). The photomicrograph shows a representative section from both groups. Scale bar, 200 μm. Error bars indicate ± SE.
- Figure 2.
Representative Western blot data from four animals showing no difference in APP or β-actin but showing significant (p < 0.04) reductions in both the α-CTF and β-CTF in the exercising animals compared with the sedentary animals.
- Figure 3.
The effect of exercise on Morris water maze performance. Average escape latencies for sedentary and exercising TgCRND8 animals in the Morris water maze are shown. Exercised animals show improved performance across the time course, with significant differences present on the first 3 d of trials, compared with the sedentary animals (*p < 0.02). Error bars indicate ± SE.
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