Article Information
- Received April 25, 2004
- Revision received November 26, 2004
- Accepted November 29, 2004
- First published January 12, 2005.
- Version of record published January 12, 2005.
Author Information
- Yue Qi-Takahara1,
- Maho Morishima-Kawashima1,
- Yu Tanimura1,
- Georgia Dolios2,
- Naoko Hirotani3,
- Yuko Horikoshi5,
- Fuyuki Kametani6,
- Masahiro Maeda5,
- Takaomi C. Saido4,
- Rong Wang2, and
- Yasuo Ihara1
- 1Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan, 2Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029-6574, 3Resources Center and 4Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, Saitama 351-0198, Japan, 5Immuno-Biological Laboratories Company, Ltd., Gunma 375-0005, Japan, and 6Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo 156-8585, Japan
Author contributions
Disclosures
- Received April 25, 2004.
- Revision received November 26, 2004.
- Accepted November 29, 2004.
This work was supported in part by a grant-in-aid for Scientific Research on Priority Areas (Advanced Brain Science Project) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Y.I.); a grant-in-aid for Science Research (C) from the Japan Society for the Promotion of Science, Japan (M.M.-K.); and a grant from the National Institutes of Health (R.W.). We thank Dr. E. H. Koo for 7WD10, M146L mtPS1, and V717F mtAPP cells, Dr. S. S. Sisodia for N2a cells overexpressing “Swedish” mtAPP695, Dr. C. Haass for human embryonic kidney cells overexpressing wtAPP695, Dr. T. Iwatsubo for polyclonal anti-PS1 antibody (anti-G1L3), Dr. H. Komano for plasmids for wtAPP695 and β-amyloid precursor protein carrying endoplasmic reticulumor TGN retention signal, J. Suzuki for L723P mtAPP cells, and Dr. S. Funamoto for constructs of dominant-negative mtPS1 and βCTF. We also thank Drs. E. H. Koo and T. Miyasaka for helpful discussions.
Correspondence should be addressed to Dr. Yasuo Ihara, Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: yihara{at}m.u-tokyo.ac.jp.
Copyright © 2005 Society for Neuroscience 0270-6474/05/250436-10$15.00/0
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