Article Figures & Data
Figures
- Figure 1.
Extinction and reacquisition of anandamide and cocaine self-administration behavior over consecutive sessions. Number of injections per session and overall rates of responding in the presence of a green light during 40 μg/kg per injection of anandamide (n = 5) and 30 μg/kg per injection of cocaine (n = 3) sessions (sessions 1-3 and 9-11) and vehicle sessions (sessions 4 - 8) are shown. Points represent means ± SEM of injections per session (a) and rates of responding (b). *p < 0.05, **p < 0.01, post hoc comparisons with the last session before vehicle extinction.
- Figure 2.
Effects of varying injection dose on self-administration of anandamide and methanandamide. Number of injections of anandamide (a) and methanandamide (b) per session, overall rates of responding in the presence of the green light signaling anandamide (c) and methanandamide (d) availability, and total anandamide (e) and methanandamide (f) intake per session are shown as a function of injection dose of drug. Each point represents the mean ± SEM of the last three sessions under each anandamide (n = 5) or methanandamide (n = 4) unit dose condition and under a vehicle condition. *p < 0.05, **p < 0.01, post hoc comparisons with the vehicle conditions. V, Vehicle.
- Figure 3.
Effects of rimonabant on responding maintained by anandamide (a), methanandamide (b), or cocaine (c) injections over consecutive sessions. Numbers of injections per session after intramuscular pretreatment with vehicle (sessions 1-3 and 9-11) or 0.03 or 0.1 mg/kg (sessions 4 - 8) rimonabant are shown in the left column. Each point represents the mean ± SEM from four (A, B) or three (c) monkeys over the last three sessions. **p < 0.01, post hoc comparisons with the last session before pretreatment with rimonabant. Representative cumulative response records (for details, see Materials and Methods) from the last anandamide (d), methanandamide (e), or cocaine (f) self-administration session with vehicle (session 3) or 0.1 mg/kg rimonabant pretreatment (session 8) are shown in the right column.
Tables
Vehicle Anandamide, 40 μg/kg per injection Monkey Self-administration history Injections per session Responses per second Injections per session Responses per second 70F4 None 3.00 ± 1.15 0.01 ± 0.01 46.67 ± 0.88 0.62 ± 0.04 66B2a None 4.67 ± 1.76 0.02 ± 0.01 47.00 ± 1.00 0.64 ± 0.06 6754 THC 8.33 ± 3.33 0.03 ± 0.01 50.00 ± 5.00 1.18 ± 0.44 1568 THC 11.00 ± 5.86 0.05 ± 0.03 51.00 ± 0.58 1.04 ± 0.08 67F4 THC 4.00 ± 1.00 0.02 ± 0.00 42.00 ± 1.00 0.40 ± 0.03 1574 Methohexital 5.33 ± 1.45 0.02 ± 0.01 45.33 ± 4.70 0.66 ± 0.21 Mean ± SEM 6.06 ± 1.23 0.02 ± 0.01 47.00 ± 1.33 0.76 ± 0.12 -
The values are calculated as mean ± SEM of the last three of five sessions under each condition.
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↵ a Monkey initially learned to self-administer anandamide but, after acquisition and subsequent extinction, was used only for methanandamide experiments.
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