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Cover image
Cover picture: This confocal image shows area CA1 of an acute rat hippocampal slice that was fixed 60 min after the induction of late long-term potentiation (LTP) by high-frequency stimulation delivered to the Schaffer collaterals. Before stimulation, the distal apical dendrites (located toward the bottom of the image) had been isolated from the cell bodies by a cut (horizontal black band). The slice was labeled for p70 S6 kinase (p70S6K) phosphorylated at T389 (red) and elongation factor 1A (green). As described in the accompanying paper, the LTP-associated increases in the phosphorylation of p70S6K and in the expression of elongation factor 1A in the isolated dendrites were siimilar to those obtained in intact CA1 dendrites, consistent with the local control of translation through the mammalian target of rapamycin pathway in LTP. For details, see the article by Tsokas et al. in this issue (pages 5833–5843).