Homer2 Is Necessary for EtOH-Induced Neuroplasticity

Homer2 KO mice exhibit aversion to EtOH. A, When assessed in a two-bottle choice task, KO mice exhibited aversion to 12% EtOH (EtOH) (v/v) (genotype × dose interaction, F_(3,111) = 5.72; p = 0.0004) but did not differ from WT in their preference for lower EtOH concentrations or for a 0.9% saccharin (Sacc) solution (p > 0.05). B, KO mice exhibited reduced EtOH intake at 12% EtOH solution (genotype × dose interaction, F_(3,111) = 2.67; p = 0.05). C, The repeated pairing of EtOH (8 injections at 0, 1, 2, or 3 g/kg, i.p.) with a distinct environment induced place conditioning in WT mice but induced place aversion in KO animals (genotype × dose interaction, F_(3,55) = 5.52; p = 0.004). Data are shown as mean ± SEM, and the number of animals used is in parentheses. ^*p < 0.05 versus 0% or 0 g/kg EtOH; ⁺p < 0.05 versus WT.