Figure 2.
Homer2 KO mice do not exhibit behavioral adaptation to repeated EtOH administration. A, Both genotypes exhibited locomotor inhibition during an acute injection of 3 g/kg EtOH (EtOH) and adaptation to daily saline injections; however, only WT mice exhibited an increase in EtOH-induced locomotion after repeated administration of 3 g/kg EtOH (dose × injection, F(1,25) = 8.92, p = 0.0002; genotype × injection number, F(1,25) = 2.77, p = 0.05). B, No genotypic differences were measured in BELs after acute or repeated EtOH administration (genotype × injection × time interaction, F(2,58) = 0.87; p = 0.58), and BEL after repeated EtOH was lower than acute EtOH in both genotypes (injection effect, F(2,29) = 2.99, p = 0.07; injection × time, F(4,58) = 4.21, p = 0.02). C, Homer2 KO mice exhibited a longer latency to regain a righting reflex after acute injection with 5 g/kg EtOH (F(1,15) = 3.21; p = 0.04). Data are shown as mean ± SEM, and the number of animals is in parentheses. *p < 0.05 versus injection 1; +p < 0.05 versus WT; #p < 0.05 versus 0 g/kg.
