Figure 3.
Homer2 KO mice do not exhibit neurochemical adaptation with repeated EtOH administration. A, The capacity of 3 g/kg EtOH to elevate extracellular levels of dopamine in the nucleus accumbens was facilitated by eight injections of EtOH in WT mice. B, Repeated EtOH did not induce a change in extracellular dopamine in KO animals (genotype × injection × time, F(11,275) = 2.31; p = 0.007). C, Repeated EtOH augmented the effect of EtOH on extracellular glutamate in WT mice. D, No such neurochemical adaptation was observed in KO animals (genotype × injection × time, F(11,297) = 1.59; p = 0.06). Data represent the mean ± SEM extracellular levels of neurotransmitter per 20 min fraction, and the number of animals is in parentheses. *p < 0.05 versus injection 1; +p < 0.05 versus WT on injection 8 (LSD post hoc tests).
