Homer2 Is Necessary for EtOH-Induced Neuroplasticity

Homer2 KO mice exhibit abnormalities in accumbens NMDA receptor function and plasma membrane expression. A, Homer2 KO mice exhibited increased sensitivity to the locomotor-stimulant effects of an intra-accumbens infusion of the competitive NMDA receptor antagonist CPP (genotype effect, F_(1,44) = 2.87, p = 0.04; genotype × dose interaction, F_(2,44) = 2.21, p = 0.07). B, Reduced membrane-bound NMDA receptor subtypes NR2a (t₍₁₃₎ = 2.271; p = 0.04) and NR2b (t₍₁₃₎ = 1.987; p = 0.07) in accumbens of KO mice. Protein data were normalized to percentage change from WT, and all data are shown as mean ± SEM. The number of animals is indicated in parentheses or in the bars. ^*p < 0.05 versus 0 nmol CPP; ⁺p < 0.05 versus WT (LSD post hoc tests or t tests).