Cover picture: Triple immunofluorescent staining reveals homeostatic scaling of vesicular glutamate transporters at excitatory synapses. Hyperexcitation in neocortical neuronal networks caused downregulation of VGLUT1 (red) at most synaptic terminals that face postsynaptic density 95 (blue), whereas VGLUT2 increased in some VGLUT1-containing synapses (yellow/blue) and at other sites (green/blue, green only). VGLUT2 is coexpressed with VGLUT1 in a novel class of excitatory neurons in the cerebral cortex. Their differential synaptic regulation may serve as negative or positive feedback regulators for neocortical excitatory transmission. For details, see the article by De Gois et al. in the August 3, 2005 issue (pages 7121–7133).