Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

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¹Neuroimmunology Laboratory, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, ²Center for Excellence in Aging and Brain Repair, Department of Neurosurgery, ³Alzheimer's Disease Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, Florida 33613, ⁴Institute of Medical Science, Saitama Medical School, Saitama 350-8550, Japan, ⁵Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, and ⁶Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06519

This work was supported by the Johnnie B. Byrd Senior Alzheimer's Center and Research Institute (J.T.) and University of South Florida College of Medicine Faculty Start-Up funds (J.T.). T.T. was supported by a Ruth L. Kirschstein National Institutes of Health–National Research Service Award–National Institute on Aging postdoctoral fellowship and an Alzheimer Association grant. We thank S. Gandy (Nathan S. Kline Institute for Psychiatry Research, New York University) and H. Steiner (Adolf Butenandt-Institute, Ludwig-Maximilians-University) for providing antibodies against the C terminus of APP (369 antibody) and S. Gandy for providing the N2a cell lines that stably overexpress human “Swedish”-mutated APP-695 or wild-type APP-695.
Correspondence should be addressed to Dr. Jun Tan, Neuroimmunology Laboratory, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613. E-mail: jtan{at}hsc.usf.edu.
DOI:10.1523/JNEUROSCI.1521-05.2005
Copyright © 2005 Society for Neuroscience 0270-6474/05/258807-08$15.00/0
↵* K.R.-Z., R.D.S., and N.S. contributed equally to this work.

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